Lacher M J, Toner K
Cancer Invest. 1986;4(2):93-100. doi: 10.3109/07357908609038252.
The menstrual cycle, pregnancies, and offspring were evaluated before and after initial combined radiation (RT) and chemotherapy with thiotepa, vinblastine, vincristine, procarbazine, and prednisone (TVPP), in 34 women between the ages of 18 and 44 (median 26.5 years) treated for Stage II and Stage III Hodgkin's disease. The median range of follow-up is 83.1 months (range 40.5-140). After therapy 94.1% (32/34) continued to menstruate. Two of the four patients over the age of 35 ceased to menstruate. All patients under the age of 35 continued to menstruate (30/30). Age at the time of diagnosis was the only factor affecting change in menses with a significant probability (p = .001) that women greater than 30 years of age will experience some change in menstrual pattern. Seventeen pregnancies occurred in 12 women after therapy; 2 had 4 elective abortions; 10 delivered 12 children with normal physical development; 1 will deliver six months from now. Twelve of thirteen patients who wanted to become pregnant have conceived. The ability to become pregnant and deliver normal children after intensive treatment with combined radiation and chemotherapy (RT/TVPP) was comparable to the patients' pretreatment record.
对34名年龄在18至44岁（中位年龄26.5岁）、接受II期和III期霍奇金病治疗的女性，在初始联合放疗（RT）和使用噻替派、长春碱、长春新碱、丙卡巴肼及泼尼松（TVPP）进行化疗前后，评估其月经周期、妊娠情况及后代情况。随访时间中位数为83.1个月（范围40.5 - 140个月）。治疗后94.1%（32/34）的患者继续有月经。4名年龄超过35岁的患者中有2名停止月经。所有35岁以下的患者继续有月经（30/30）。诊断时的年龄是影响月经变化的唯一因素，30岁以上女性月经模式出现某些变化的概率显著（p = 0.001）。治疗后12名女性发生了17次妊娠；2名进行了4次选择性流产；10名分娩了12名身体发育正常的儿童；1名将在6个月后分娩。13名想要怀孕的患者中有12名已受孕。联合放疗和化疗（RT/TVPP）强化治疗后怀孕并分娩正常儿童的能力与患者治疗前的记录相当。
