Andrieu J M, Ochoa-Molina M E
Cancer. 1983 Aug 1;52(3):435-8. doi: 10.1002/1097-0142(19830801)52:3<435::aid-cncr2820520308>3.0.co;2-1.
The menstrual cycle, pregnancies and offspring were studied before and after MOPP therapy (3 or 6 cycles) in women treated for Hodgkin's disease between 1972 and 1976. All were between 16 and 45 years of age at diagnosis; none received subdiaphragmatic irradiation. This study was carried out through a questionnaire. Before treatment, all patients had normal menses; 72 pregnancies occurred; 61 children were born, 2 with minor abnormalities. After therapy, oligo or amenorrhea occurred in 26.4% of the patients. This percentage was different according to the age at therapy: 4.8% before age 30, 61.5% after age 30 (P less than 0.001); 50 women (73.6%) continued to menstruate normally, 22 of whom had 30 pregnancies; 22 children were born, 1 with a minor abnormality. All have normal physical and intellectual development. For the 73.6% of women who continued to menstruate, MOPP therapy seems to have no impact on fertility, pregnancies, and offspring.
对1972年至1976年间接受霍奇金病治疗的女性在MOPP疗法（3个或6个疗程）前后的月经周期、妊娠及后代情况进行了研究。所有患者诊断时年龄在16至45岁之间；均未接受膈下照射。本研究通过问卷调查进行。治疗前，所有患者月经正常；发生72次妊娠；出生61名儿童，其中2名有轻微异常。治疗后，26.4%的患者出现月经过少或闭经。该百分比因治疗时年龄而异：30岁前为4.8%，30岁后为61.5%（P<0.001）；50名女性（73.6%）月经仍正常，其中22名有30次妊娠；出生22名儿童，1名有轻微异常。所有儿童身体和智力发育均正常。对于73.6%仍有月经的女性，MOPP疗法似乎对生育力、妊娠及后代无影响。
