Hayat Maham, Zia Hassaan, Nusrat Salman
Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA,
Section of Digestive Diseases & Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Patient Relat Outcome Meas. 2019 Feb 12;10:43-47. doi: 10.2147/PROM.S157905. eCollection 2019.
Chronic idiopathic constipation, if inadequately treated, can be bothersome with a detrimental effect on patients' quality of life (QOL). This may also result in frequent health care visits, increasing the burden of this ailment's medical cost. Management strategies, focused on lifestyle changes, include increased exercise, a high-fiber diet, and toilet training. Pharmacologic options include fiber supplementation, laxatives, serotonergic agents, and prosecretory agents such as lubiprostone. In this review, we were able to conclude that lubiprostone, when used for chronic idiopathic constipation, has a significantly beneficial effect on both patients' symptoms and their QOL. In multiple randomized controlled trials, it has been found to have increased the number of spontaneous bowel movements at different time endpoints. Corresponding improvements were also observed for abdominal bloating, discomfort, stool frequency, and straining symptoms among patients.
慢性特发性便秘若治疗不当，会给患者带来困扰，对其生活质量（QOL）产生不利影响。这还可能导致频繁就医，增加这种疾病的医疗费用负担。以生活方式改变为重点的管理策略包括增加运动、高纤维饮食和排便训练。药物治疗选择包括补充纤维、使用泻药、血清素能药物以及促分泌剂如鲁比前列酮。在本综述中，我们能够得出结论，鲁比前列酮用于慢性特发性便秘时，对患者的症状及其生活质量均有显著有益影响。在多项随机对照试验中，已发现它在不同时间点增加了自主排便次数。患者的腹胀、不适、排便频率和排便费力症状也有相应改善。
