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2
Influence of prostate weight, obesity and height on surgical outcomes of robot-assisted laparoscopic radical prostatectomy in Korean men.前列腺重量、肥胖及身高对韩国男性机器人辅助腹腔镜根治性前列腺切除术手术结果的影响。
J Robot Surg. 2008;1(4):287-90. doi: 10.1007/s11701-007-0057-3. Epub 2007 Dec 21.
3
Change in prostate volume during extreme hypo-fractionation analysed with MRI.通过MRI分析极端低分割放疗期间前列腺体积的变化。
Radiat Oncol. 2014 Jan 13;9:22. doi: 10.1186/1748-717X-9-22.
4
Electromagnetic transponders indicate prostate size increase followed by decrease during the course of external beam radiation therapy.电磁应答器显示前列腺在外照射放射治疗过程中先增大后减小。
Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1350-7. doi: 10.1016/j.ijrobp.2009.12.053. Epub 2010 Jun 3.
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MRI-based preplanning in low-dose-rate prostate brachytherapy.基于磁共振成像的低剂量率前列腺近距离放射治疗术前规划
Radiother Oncol. 2008 Jul;88(1):115-20. doi: 10.1016/j.radonc.2007.09.012. Epub 2007 Oct 22.
6
Toxicity profile with a large prostate volume after external beam radiotherapy for localized prostate cancer.局限性前列腺癌外照射放疗后前列腺体积较大时的毒性特征。
Int J Radiat Oncol Biol Phys. 2008 Jan 1;70(1):83-9. doi: 10.1016/j.ijrobp.2007.05.051. Epub 2007 Sep 12.
7
Quantification of shape variation of prostate and seminal vesicles during external beam radiotherapy.外照射放疗期间前列腺和精囊形状变化的量化
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Neoadjuvant androgen deprivation and prostate gland shrinkage during conformal radiotherapy.适形放疗期间的新辅助雄激素剥夺与前列腺缩小
Radiother Oncol. 2003 Feb;66(2):151-7. doi: 10.1016/s0167-8140(03)00031-8.
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Prostate position late in the course of external beam therapy: patterns and predictors.外照射治疗后期前列腺位置：模式与预测因素
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体外放射治疗期间前列腺、膀胱和直肠壁大小变化的研究。

Investigation of the changes in the prostate, bladder, and rectal wall sizes during external beam radiotherapy.

作者信息

Tanaka Osamu, Seike Kensaku, Taniguchi Takuya, Ono Kousei, Matsuo Masayuki

机构信息

Asahi University Hospital, Department of Radiation Oncology, Japan.

Gifu Municipal Hospital, Department of Urology, Japan.

出版信息

Rep Pract Oncol Radiother. 2019 Mar-Apr;24(2):204-207. doi: 10.1016/j.rpor.2019.02.005. Epub 2019 Feb 22.

DOI:10.1016/j.rpor.2019.02.005
PMID:30858764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6395849/
Abstract

AIM AND BACKGROUND

The change in the prostate size for radiotherapy has not yet been elucidated. The coverage of radiation dose is affected by changes in the prostate size. We evaluated the changes in the prostate, rectum, and bladder wall sizes during IMRT of fraction 2 Gy/day using MRI.

MATERIALS AND METHODS

Twenty-four patients with prostate cancer were enrolled in this study. MRI was performed at three time points. While the initial MRI was performed before the start of radiotherapy (RT), the second MRI was performed at 38 Gy (range: 36-40 Gy), which represented the halfway point of the RT course. The last MRI was performed on the day of completion of the RT course (76 Gy; range: 74-78 Gy). We estimated the prostate, rectum, and bladder wall sizes at three time points.

RESULTS

We observed no significant difference between the estimated sizes of the prostate during RT in all three phases. In addition, the volume of the rectal wall remained unchanged in all phases. However, the volume of the bladder wall significantly decreased from the initial to the last time points. Furthermore, the standard deviation (SD) obtained by subtracting the final size from the initial one was large (mean, 30.1; SD, 10.1).

CONCLUSIONS

The volume of the bladder wall decreased during IMRT. The range of subtraction of the volume of the bladder wall was extensive. Thus, the estimation of the bladder wall may be useful to reduce the inter-fraction variation.

摘要

目的与背景

放射治疗期间前列腺大小的变化尚未阐明。前列腺大小的变化会影响辐射剂量的覆盖范围。我们使用磁共振成像（MRI）评估了在每天2Gy分次调强放射治疗（IMRT）期间前列腺、直肠和膀胱壁大小的变化。

材料与方法

本研究纳入了24例前列腺癌患者。在三个时间点进行MRI检查。初始MRI在放射治疗（RT）开始前进行，第二次MRI在38Gy（范围：36 - 40Gy）时进行，这代表RT疗程的中点。最后一次MRI在RT疗程完成当天（76Gy；范围：74 - 78Gy）进行。我们在三个时间点估计前列腺、直肠和膀胱壁的大小。

结果

我们观察到在所有三个阶段的RT期间，前列腺的估计大小之间无显著差异。此外，直肠壁的体积在所有阶段均保持不变。然而，膀胱壁的体积从初始时间点到最后时间点显著减小。此外，用初始大小减去最终大小得到的标准差（SD）较大（平均值为30.1；SD为10.1）。

结论

在IMRT期间膀胱壁的体积减小。膀胱壁体积减小的范围较大。因此，膀胱壁的估计可能有助于减少分次间的差异。