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肉毒杆菌神经毒素联合肌电图/超声引导治疗颈部肌张力障碍

Management of cervical dystonia with botulinum neurotoxins and EMG/ultrasound guidance.

作者信息

Castagna Anna, Albanese Alberto

机构信息

IRCCS Fondazione Don Carlo Gnocchi (AC), Servizio di Analisi Funzione Locomotoria; Università Cattolica del Sacro Cuore (AA), Istituto di Neurologia; and IRCCS Istituto Clinico Humanitas (AA), Unità Operativa Neurologia, Rozzano, Milano.

出版信息

Neurol Clin Pract. 2019 Feb;9(1):64-73. doi: 10.1212/CPJ.0000000000000568.

DOI:10.1212/CPJ.0000000000000568
PMID:30859009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6382379/
Abstract

PURPOSE OF REVIEW

We provide a practical guide on the use of electromyography (EMG) and ultrasound (US) to assist botulinum neurotoxin (BoNT) treatment in patients with cervical dystonia (CD).

RECENT FINDINGS

US and EMG guidance improve BoNT treatment in CD. Their use is particularly valuable for targeting deep neck muscles and managing complex cases. There is also evidence that adverse events are reduced when superficial or intermediate layer muscles are injected with assisted guidance.

SUMMARY

A structured clinical approach, based on functional neck anatomy, guides CD assessment and BoNT treatment. Muscles are selected according to clinical, EMG and US findings. US provides anatomical visualization, while EMG complements by detecting muscle activity. We review here the current practice for assisted treatment of CD through BoNT cycles. We also describe how to recognize and manage the main adverse events.

摘要

综述目的

我们提供一份关于使用肌电图(EMG)和超声(US)辅助治疗颈部肌张力障碍(CD)患者肉毒杆菌神经毒素(BoNT)的实用指南。

最新发现

超声和肌电图引导可改善颈部肌张力障碍的肉毒杆菌神经毒素治疗。它们的使用对于靶向颈部深层肌肉和处理复杂病例特别有价值。也有证据表明,在辅助引导下注射浅层或中层肌肉时,不良事件会减少。

总结

基于功能性颈部解剖结构的结构化临床方法可指导颈部肌张力障碍的评估和肉毒杆菌神经毒素治疗。根据临床、肌电图和超声检查结果选择肌肉。超声提供解剖可视化,而肌电图则通过检测肌肉活动起到补充作用。我们在此回顾通过肉毒杆菌神经毒素周期辅助治疗颈部肌张力障碍的当前实践。我们还描述了如何识别和处理主要不良事件。

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本文引用的文献

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Neurol Clin Pract. 2016 Jun;6(3):281-286. doi: 10.1212/CPJ.0000000000000243.
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Cochrane Database Syst Rev. 2017 Dec 12;12(12):CD003633. doi: 10.1002/14651858.CD003633.pub3.
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Cervical sensorimotor control in idiopathic cervical dystonia: A cross-sectional study.特发性颈肌张力障碍患者的颈椎运动感觉控制:一项横断面研究。
Brain Behav. 2017 Aug 11;7(9):e00735. doi: 10.1002/brb3.735. eCollection 2017 Sep.
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Parkinsonism Relat Disord. 2017 Nov;44:119-123. doi: 10.1016/j.parkreldis.2017.07.034. Epub 2017 Aug 1.
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Clinical Practice: Evidence-Based Recommendations for the Treatment of Cervical Dystonia with Botulinum Toxin.临床实践:肉毒杆菌毒素治疗颈部肌张力障碍的循证推荐
Front Neurol. 2017 Feb 24;8:35. doi: 10.3389/fneur.2017.00035. eCollection 2017.
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J Neurol. 2016 Aug;263(8):1663-4. doi: 10.1007/s00415-016-8202-4. Epub 2016 Jun 17.
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Neurology. 2016 May 10;86(19):1818-26. doi: 10.1212/WNL.0000000000002560. Epub 2016 Apr 18.
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British Neurotoxin Network recommendations for managing cervical dystonia in patients with a poor response to botulinum toxin.英国神经毒素网络关于肉毒杆菌毒素反应不佳的颈肌张力障碍患者管理的建议。
Pract Neurol. 2016 Aug;16(4):288-95. doi: 10.1136/practneurol-2015-001335. Epub 2016 Mar 14.
9
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10
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J Neurol. 2015 Oct;262(10):2201-13. doi: 10.1007/s00415-015-7703-x. Epub 2015 Apr 1.