Department of Neurology, Albert Szent-Györgyi Clinical Centre, Albert Szent-Györgyi Faculty of Medicine, University of Szeged, Szeged, Hungary.
Department of Neurology, Elbe Klinik Stade, Stade, Germany.
Mov Disord Clin Pract. 2024 Aug;11(8):1013-1017. doi: 10.1002/mdc3.14118. Epub 2024 Jun 3.
Due to its heterogeneous manifestation an individualized approach to reach therapeutic goals in cervical dystonia (CD) is advantageous.
The aim of the current study was to adapt goal attainment scaling (GAS) to drive the management of CD.
38 patients with CD, regularly treated with botulinum neurotoxin (BoNT), were involved in the current exploratory observational pilot study. GAS, including domains of motor, pain, disability, and psychiatric features, was applied to set up individualized goals with the calculation of initial GAS T-scores. Following at least 4 BoNT injection cycles, patients were reassessed whether they reached the pre-set goals.
The initial GAS T-scores (median: 36.9, range: 22.8-40) significantly improved (P < 0.001) to the end of the study (the median of final GAS T-scores: 50, range: 25.5-63.6).
The applicability of GAS in CD patients was confirmed, but further large-scale studies are needed refining this innovative approach.
由于表现形式多样，在治疗颈部肌张力障碍 (CD) 时采用个体化方法来达到治疗目标是有益的。
本研究旨在采用目标实现评分法 (GAS) 来管理 CD。
本探索性观察性试点研究纳入了 38 例定期接受肉毒毒素 (BoNT) 治疗的 CD 患者。GAS 包括运动、疼痛、残疾和精神特征等领域，用于设定个体化目标，并计算初始 GAS T 评分。在至少 4 次 BoNT 注射周期后，评估患者是否达到预设目标。
初始 GAS T 评分（中位数：36.9，范围：22.8-40）在研究结束时显著改善（P<0.001）（最终 GAS T 评分中位数：50，范围：25.5-63.6）。
GAS 在 CD 患者中的适用性得到了证实，但需要进一步的大规模研究来完善这一创新方法。
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