Loftus John P, DeRosa Sage, Struble Angela M, Randolph John F, Wakshlag Joseph J
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA,
Vet Med (Auckl). 2019 Feb 12;10:9-16. doi: 10.2147/VMRR.S189709. eCollection 2019.
This study sought to determine the efficacy of a therapeutic iodine-restricted diet during a 12 -month interval in cats with moderately to severely increased total thyroxine (TT4) concentrations.
Eight hyperthyroid cats with serum creatinine <2.0 mg/dL and TT4 >6.0 µg/dL (reference interval 1.5-4.0 µg/dL) were enrolled. Each cat underwent an initial physical examination, complete blood count, serum chemistry panel, thyroid profile, thyroid scintigraphy, and echocardiogram. Physical examination and all blood samplings were repeated at 1, 2, 3, 6, and 12 months after enrollment. Clients were instructed to feed only the therapeutic iodine-restricted diet throughout the entire study.
Median TT4 was 8.4 (range 6.2-24.0) µg/dL at study onset. Thyroid scintigraphy was abnormal in all cats, confirming hyperthyroidism. Six out of eight cats had normal serum TT4 after 4 weeks of feeding the therapeutic diet. The two cats that did not achieve normalization of TT4 at 4 weeks had the highest initial TT4 concentrations. Three cats were withdrawn from the study due to emergence of chronic kidney disease.
An iodine-restricted diet was able to control moderate-to-severe hyperthyroidism in most (six out of eight) of the cats by 4 weeks. Cats with highest baseline TT4 took substantially longer before TT4 concentrations normalized, if at all.
本研究旨在确定在12个月期间，对总甲状腺素（TT4）浓度中度至重度升高的猫采用治疗性限碘饮食的疗效。
纳入8只血清肌酐<2.0mg/dL且TT4>6.0μg/dL（参考区间1.5 - 4.0μg/dL）的甲状腺功能亢进猫。每只猫均接受了初始体格检查、全血细胞计数、血清化学检查、甲状腺功能检查、甲状腺闪烁扫描和超声心动图检查。在入组后的1、2、3、6和12个月重复进行体格检查和所有血液采样。在整个研究过程中，指导主人仅喂食治疗性限碘饮食。
研究开始时，TT4中位数为8.4（范围6.2 - 24.0）μg/dL。所有猫的甲状腺闪烁扫描均异常，证实为甲状腺功能亢进。在喂食治疗性饮食4周后，8只猫中有6只的血清TT4恢复正常。4周时TT4未恢复正常的2只猫，其初始TT4浓度最高。3只猫因出现慢性肾病而退出研究。
限碘饮食能够在4周内使大多数（8只中的6只）猫的中度至重度甲状腺功能亢进得到控制。基线TT4最高的猫，其TT4浓度恢复正常所需的时间（如果能恢复正常的话）要长得多。
