Nestico P F, Morganroth J
Cardiol Clin. 1986 May;4(2):285-303.
The frequency of ventricular arrhythmias increases with age. Several factors make elderly people more prone to antiarrhythmic drug toxicity. Familiarity with the changes in the pharmacokinetics and pharmacodynamics of antiarrhythmic agents may reduce or prevent adverse response in this patient population.
室性心律失常的发生率随年龄增长而增加。有几个因素使老年人更容易发生抗心律失常药物毒性。熟悉抗心律失常药物的药代动力学和药效学变化可能会减少或预防该患者群体的不良反应。