Stewart Adam
Department of Infectious Diseases, Sunshine Coast University Hospital, Queensland; Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Australia.
Int J Mycobacteriol. 2019 Jan-Mar;8(1):98-100. doi: 10.4103/ijmy.ijmy_17_19.
Primary cutaneous Mycobacterium avium complex (MAC) infection is a rare diagnosis in both immunocompetent and immunocompromised hosts. Disseminated MAC almost always occurs in the setting of advanced HIV infection and typically results from initial pulmonary or gastrointestinal disease. We describe a case of a 70-year-old female with systemic sclerosis and severe tumoral calcinosis that developed disseminated MAC infection secondary to deep cutaneous disease. Treatment was complicated by multiple significant drug interactions, patient comorbidities, as well as an inability to safely and completely surgically resect her infected soft tissue for source control.
原发性皮肤鸟分枝杆菌复合体（MAC）感染在免疫功能正常和免疫功能低下的宿主中都是一种罕见的诊断。播散性MAC几乎总是发生在晚期HIV感染的情况下，通常由初始的肺部或胃肠道疾病引起。我们描述了一例70岁女性患者，她患有系统性硬化症和严重的肿瘤性钙化，因深部皮肤疾病继发播散性MAC感染。治疗因多种显著的药物相互作用、患者合并症以及无法安全、彻底地手术切除其感染的软组织以控制感染源而变得复杂。
