Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.
Chem Commun (Camb). 2019 Mar 26;55(26):3741-3744. doi: 10.1039/c9cc00407f.
We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core-shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.
我们通过聚合诱导自组装（PISA）合成了基于聚（2-乙基-2-恶唑啉）（PEtOx）的纳米物体。首先，通过阳离子开环聚合和点击化学合成了结构明确的 PEtOx 大分子链转移剂。由这些 PEtOx 介导的 2-羟丙基甲基丙烯酸酯的光引发 PISA 产生了跨越全核壳形态范围的纳米物体。这些纳米粒子在体外或体内表现出高生物相容性和隐形特性，以及温敏行为。
