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2
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The Impact of Baseline 25-Hydroxyvitamin D Level and Gestational Age on Prenatal Vitamin D Supplementation to Prevent Offspring Asthma or Recurrent Wheezing.基线 25-羟维生素 D 水平和胎龄对预防子代哮喘或反复喘息的产前维生素 D 补充的影响。
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本文引用的文献

1
Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring.孕期内摄入鱼油来源的脂肪酸与后代喘息和哮喘的相关性研究。
N Engl J Med. 2016 Dec 29;375(26):2530-9. doi: 10.1056/NEJMoa1503734.
2
In utero exposure to 25-hydroxyvitamin D and risk of childhood asthma, wheeze, and respiratory tract infections: A meta-analysis of birth cohort studies.子宫内暴露于 25-羟维生素 D 与儿童哮喘、喘息和呼吸道感染风险的关系：一项基于出生队列研究的荟萃分析。
J Allergy Clin Immunol. 2017 May;139(5):1508-1517. doi: 10.1016/j.jaci.2016.06.065. Epub 2016 Sep 14.
3
Effect of Vitamin D3 Supplementation During Pregnancy on Risk of Persistent Wheeze in the Offspring: A Randomized Clinical Trial.孕期补充维生素 D3 对后代持续性喘息风险的影响：一项随机临床试验。
JAMA. 2016 Jan 26;315(4):353-61. doi: 10.1001/jama.2015.18318.
4
Endotyping early childhood asthma by quantitative symptom assessment.通过定量症状评估对儿童哮喘进行表型分型。
J Allergy Clin Immunol. 2011 May;127(5):1155-64.e2. doi: 10.1016/j.jaci.2011.02.007. Epub 2011 Mar 24.

孕期高剂量维生素 D 补充与儿童 6 岁时哮喘的关系。

High-Dose Vitamin D Supplementation During Pregnancy and Asthma in Offspring at the Age of 6 Years.

机构信息

Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte University Hospital, Copenhagen, Denmark.

出版信息

JAMA. 2019 Mar 12;321(10):1003-1005. doi: 10.1001/jama.2019.0052.

DOI:10.1001/jama.2019.0052
PMID:30860552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6439670/
Abstract

This long-term follow-up of a randomized trial reporting no apparent effect of high-dose vs standard-dose prenatal vitamin D supplementation on wheezing in children at the age of 3 years extends the findings an additional 3 years and describes asthma risk at the age of 6 years.

摘要

本研究对一项随机试验进行了长期随访，该试验报告称高剂量与标准剂量产前维生素 D 补充对 3 岁儿童喘息无明显影响，本研究将随访时间延长了 3 年，并描述了 6 岁时哮喘的风险。