Grigg Jonathan, Barratt Benjamin, Bønnelykke Klaus, Custovic Adnan, Ege Markus, Pasquali Christian, Palomares Oscar, Shaheen Seif, Sokolowska Milena, Vercelli Donata, Maizels Rick, von Mutius Erika
Institute of Asthma and Allergy Prevention, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Blizard Institute, Queen Mary University of London, London, UK.
Pediatr Pulmonol. 2025 Jan;60(1):e27401. doi: 10.1002/ppul.27401. Epub 2024 Dec 3.
This report is a summary of the presentations given at the European Respiratory Society's Research Seminar on Asthma Prevention. The seminar reviewed both epidemiological and mechanistic studies and concluded that; (i) reducing exposure of pregnant women and children to air pollution will reduce incident asthma, (ii) there are promising data that both fish oil and a component of raw cow's milk prevent asthma, and (iii) modulating trained immunity by either mimicking helminth infection or oral and sublingual bacterial products is a promising area of research.
本报告是在欧洲呼吸学会哮喘预防研究研讨会上所作报告的总结。该研讨会回顾了流行病学和机制研究，并得出以下结论：（i）减少孕妇和儿童接触空气污染将降低哮喘发病率；（ii）有前景的数据表明，鱼油和生牛奶的一种成分均可预防哮喘；（iii）通过模拟蠕虫感染或口服及舌下使用细菌产物来调节训练有素的免疫力是一个有前景的研究领域。
