Bauer Zaith A., De Jesus Orlando, Bunin Jessica L.
Tripler Army Medical Center
University of Puerto Rico, Medical Sciences Campus, Neurosurgery Section
Consciousness is the state of awareness of oneself and the surrounding environment and the ability to respond to external stimuli. Reduced alertness, diminished wakefulness, and a decreased awareness of oneself and the environment all characterize impaired consciousness. Although some patients may naturally regain full consciousness without medical intervention, others require intensive care and intricate diagnostic assessments. A coma is a profound and occasionally extended state of unconsciousness. According to Plum and Posner, a coma is defined as a state of unresponsiveness in which the patient lies with their eyes closed and cannot be awakened to respond appropriately to stimuli, even with vigorous stimulation. The Glasgow Coma Scale (GCS) is a medical tool that objectively measures a coma's severity. GCS scores are valuable in predicting the prognosis for patients with traumatic brain injuries (TBIs), subarachnoid hemorrhages, and bacterial meningitis. During periods of unconsciousness, patients lose their protective reflexes and sensory responses, rendering them vulnerable to aspiration, anoxic brain injuries, airway obstruction, and skin ulcerations. The causes of persistent unconsciousness can be either reversible or permanent. Potential contributors to diminished consciousness include damage to the ascending reticular activating system (RAS), cerebral hemispheres, and toxic or metabolic disruptions. This review explores the etiologies and physiological aspects of reduced consciousness, with a focus on the significant role of the interprofessional healthcare team in assessing and managing this condition to improve patient outcomes and reduce complications.
意识是对自身及周围环境的觉知状态,以及对外部刺激作出反应的能力。警觉性降低、清醒程度减弱、对自身及环境的感知下降均为意识障碍的特征。尽管一些患者可能无需医疗干预就能自然恢复完全意识,但另一些患者则需要重症监护和复杂的诊断评估。昏迷是一种深度且有时会持续较长时间的无意识状态。根据普拉姆和波斯纳的定义,昏迷是一种无反应状态,患者双眼紧闭躺着,即使受到强烈刺激也无法被唤醒并作出适当反应。格拉斯哥昏迷量表(GCS)是一种客观测量昏迷严重程度的医疗工具。GCS评分对于预测创伤性脑损伤(TBI)、蛛网膜下腔出血和细菌性脑膜炎患者的预后很有价值。在无意识期间,患者会失去保护性反射和感觉反应,使其易发生误吸、缺氧性脑损伤、气道阻塞和皮肤溃疡。持续性无意识的原因可能是可逆的,也可能是永久性的。导致意识减弱的潜在因素包括上行网状激活系统(RAS)、大脑半球受损,以及中毒或代谢紊乱。本综述探讨意识降低的病因和生理方面,重点关注跨专业医疗团队在评估和管理这种情况以改善患者预后和减少并发症方面的重要作用。