Association of and gene polymorphisms with Wilms tumor risk: a four-center case-control study.

Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether gene variants predispose individuals to Wilms tumor. Four SNPs in were genotyped in 355 Wilms tumor cases and 1070 controls. The SNPs included rs12587 G>T, rs7973450 A>G and rs7312175 G>A in , and rs2273267 A>T in . Individuals harboring the rs12587 GT genotype were more likely to develop Wilms tumor than those carrying the GG genotype (adjusted odds ratio [OR]=1.30, 95% confidence interval [CI]=1.004-1.68, =0.046). However, the other three SNPs seemed not to influence the risk for Wilms tumor. Compared to individuals without a risk genotype, those harboring one to three risk genotypes had an adjusted OR of 1.28 for developing Wilms tumor (95% CI=1.002-1.64, =0.048). Stratification analysis revealed that rs12587 GT/TT was associated with Wilms tumor risk in children >18 months old (adjusted OR=1.39, 95% CI=1.02-1.89, =0.037). Our findings indicate that the rs12587 G>T polymorphism in is associated with increased Wilms tumor susceptibility.