Wang Zhiyuan, Zhuo Zhenjian, Li Linyan, Hua Rui-Xi, Li Li, Zhang Jiao, Cheng Jiwen, Zhou Haixia, Li Suhong, He Jing, Yan Shan
Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650031, Yunnan, China.
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
J Cancer. 2021 Aug 26;12(20):6165-6169. doi: 10.7150/jca.62154. eCollection 2021.
YTHDF2 is responsible for maintaining the dynamic N-methyladenosine (mA) modification balance and influences a variety of cancers. We tested whether gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However, the rs3738067 A>G polymorphism showed no statistical significance with Wilms tumor susceptibility. Stratification analysis also revealed that there was no remarkable association of rs3738067 variant AG/GG genotype with Wilms tumor risk in every subgroup (age, gender, and clinical stages). In all, the results indicated gene rs3738067 A>G polymorphism could not alter Wilms tumor risk significantly.
YTHDF2负责维持动态的N-甲基腺苷（m⁶A）修饰平衡，并影响多种癌症。我们通过对中国儿童样本（450例病例和1317例对照）进行基因分型，测试了基因rs3738067 A>G多态性是否与肾母细胞瘤有关。然而，rs3738067 A>G多态性与肾母细胞瘤易感性无统计学意义。分层分析还显示，在每个亚组（年龄、性别和临床分期）中，rs3738067变异AG/GG基因型与肾母细胞瘤风险均无显著关联。总体而言，结果表明基因rs3738067 A>G多态性不会显著改变肾母细胞瘤风险。
