打破对称：终于找到了蠕虫线索。
Breaking Symmetry: Worm Cue Finally Found.
机构信息
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
出版信息
Dev Cell. 2019 Mar 11;48(5):593-594. doi: 10.1016/j.devcel.2019.02.018.
Abstract
In this issue of Developmental Cell, Zhao et al. (2019) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin to establish anterior-posterior polarity in the C. elegans zygote, diffusing from centrosomes to the overlying cortex to phosphorylate yet to be identified target(s).
摘要
在本期《发育细胞》中，Zhao 等人（2019 年）表明，Aurora A 激酶 AIR-1 是长期寻求的线索，可下调皮质肌动球蛋白以在 C. elegans 合子中建立前后极性，从中心体扩散到上面的皮质以磷酸化尚未确定的靶标。
相似文献
1
Breaking Symmetry: Worm Cue Finally Found.打破对称：终于找到了蠕虫线索。
Dev Cell. 2019 Mar 11;48(5):593-594. doi: 10.1016/j.devcel.2019.02.018.
2
Aurora A depletion reveals centrosome-independent polarization mechanism in .极光 A 耗竭揭示了 中中心体独立的极化机制。
Elife. 2019 Feb 26;8:e44552. doi: 10.7554/eLife.44552.
3
Centrosome Aurora A gradient ensures single polarity axis in C. elegans embryos.中心体 Aurora A 梯度确保秀丽隐杆线虫胚胎中的单极轴。
Biochem Soc Trans. 2020 Jun 30;48(3):1243-1253. doi: 10.1042/BST20200298.
4
Aurora-A Breaks Symmetry in Contractile Actomyosin Networks Independently of Its Role in Centrosome Maturation.极光 A 激酶在有丝分裂纺锤体组装和染色体分离中的作用及其调控机制
Dev Cell. 2019 Mar 11;48(5):631-645.e6. doi: 10.1016/j.devcel.2019.02.012.
5
Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in embryos.中心体极光激酶 A 调控 RhoGEF ECT-2 的定位，确保胚胎中单个 PAR-2 极性轴的形成。
Development. 2019 Nov 21;146(22):dev174565. doi: 10.1242/dev.174565.
6
Regulated Activation of the PAR Polarity Network Ensures a Timely and Specific Response to Spatial Cues.调控 PAR 极性网络的激活以确保对空间线索做出及时且特异的反应。
Curr Biol. 2019 Jun 17;29(12):1911-1923.e5. doi: 10.1016/j.cub.2019.04.058. Epub 2019 May 30.
7
Symmetry breaking in C. elegans: another gift from the sperm.秀丽隐杆线虫中的对称性破缺：精子带来的另一份礼物。
Dev Cell. 2006 Sep;11(3):273-4. doi: 10.1016/j.devcel.2006.08.007.
8
Mechanochemical Control of Symmetry Breaking in the Zygote.合子中对称性破缺的机械化学控制
Front Cell Dev Biol. 2021 Jan 18;8:619869. doi: 10.3389/fcell.2020.619869. eCollection 2020.
9
Sustained centrosome-cortical contact ensures robust polarization of the one-cell C. elegans embryo.持续的中心体-皮质接触确保了单细胞秀丽隐杆线虫胚胎的稳健极化。
Dev Biol. 2017 Feb 15;422(2):135-145. doi: 10.1016/j.ydbio.2016.12.025. Epub 2017 Jan 6.
10
Cellular symmetry breaking during Caenorhabditis elegans development.秀丽隐杆线虫发育过程中的细胞对称破缺。
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a003400. doi: 10.1101/cshperspect.a003400.
本文引用的文献
1
Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in embryos.中心体极光激酶 A 调控 RhoGEF ECT-2 的定位，确保胚胎中单个 PAR-2 极性轴的形成。
Development. 2019 Nov 21;146(22):dev174565. doi: 10.1242/dev.174565.
2
Aurora-A Breaks Symmetry in Contractile Actomyosin Networks Independently of Its Role in Centrosome Maturation.极光 A 激酶在有丝分裂纺锤体组装和染色体分离中的作用及其调控机制
Dev Cell. 2019 Mar 11;48(5):631-645.e6. doi: 10.1016/j.devcel.2019.02.012.
3
Aurora A depletion reveals centrosome-independent polarization mechanism in .极光 A 耗竭揭示了 中中心体独立的极化机制。
Elife. 2019 Feb 26;8:e44552. doi: 10.7554/eLife.44552.
4
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.TPXL-1 通过激活 Aurora A，在胞质分裂过程中从极性皮层中清除收缩环成分。
J Cell Biol. 2018 Mar 5;217(3):837-848. doi: 10.1083/jcb.201706021. Epub 2018 Jan 8.
5
Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.极光激酶A有助于基于纺锤体极的错误校正途径。
Curr Biol. 2015 Jul 20;25(14):1842-51. doi: 10.1016/j.cub.2015.06.021. Epub 2015 Jul 9.
6
Polarity establishment, asymmetric division and segregation of fate determinants in early C. elegans embryos.秀丽隐杆线虫早期胚胎中极性的建立、不对称分裂及命运决定因子的分离
WormBook. 2014 Dec 30:1-43. doi: 10.1895/wormbook.1.30.2.
7
Centrosomes can initiate a polarity axis from any position within one-cell C. elegans embryos.中心体可以在单细胞 C. elegans 胚胎的任意位置起始一个极性轴。
Curr Biol. 2012 Apr 10;22(7):583-9. doi: 10.1016/j.cub.2012.01.064. Epub 2012 Mar 15.
8
A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.中心体和极光激酶A在核膜破裂中不依赖微管的作用。
Dev Cell. 2007 Apr;12(4):515-29. doi: 10.1016/j.devcel.2007.01.019.
9
Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans.秀丽隐杆线虫的中心体成熟需要极光激酶A。
J Cell Biol. 2001 Dec 24;155(7):1109-16. doi: 10.1083/jcb.200108051. Epub 2001 Dec 17.
10
A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos.一种高度保守的中心体激酶AIR-1，是秀丽隐杆线虫胚胎中精确的细胞周期进程和发育因子分离所必需的。
Development. 1998 Nov;125(22):4391-402. doi: 10.1242/dev.125.22.4391.
Zotero 插件