Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
Dev Cell. 2019 Mar 11;48(5):593-594. doi: 10.1016/j.devcel.2019.02.018.
In this issue of Developmental Cell, Zhao et al. (2019) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin to establish anterior-posterior polarity in the C. elegans zygote, diffusing from centrosomes to the overlying cortex to phosphorylate yet to be identified target(s).
在本期《发育细胞》中，Zhao 等人（2019 年）表明，Aurora A 激酶 AIR-1 是长期寻求的线索，可下调皮质肌动球蛋白以在 C. elegans 合子中建立前后极性，从中心体扩散到上面的皮质以磷酸化尚未确定的靶标。
