打破对称：终于找到了蠕虫线索。
Breaking Symmetry: Worm Cue Finally Found.
机构信息
Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Department of Zoology, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T1Z3, Canada.
出版信息
Dev Cell. 2019 Mar 11;48(5):593-594. doi: 10.1016/j.devcel.2019.02.018.
Abstract
In this issue of Developmental Cell, Zhao et al. (2019) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin to establish anterior-posterior polarity in the C. elegans zygote, diffusing from centrosomes to the overlying cortex to phosphorylate yet to be identified target(s).
摘要
在本期《发育细胞》中，Zhao 等人（2019 年）表明，Aurora A 激酶 AIR-1 是长期寻求的线索，可下调皮质肌动球蛋白以在 C. elegans 合子中建立前后极性，从中心体扩散到上面的皮质以磷酸化尚未确定的靶标。
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本文引用的文献
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Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in embryos.
Development. 2019 Nov 21;146(22):dev174565. doi: 10.1242/dev.174565.
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Aurora-A Breaks Symmetry in Contractile Actomyosin Networks Independently of Its Role in Centrosome Maturation.
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