Fatourechi Vahab
a Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Expert Rev Endocrinol Metab. 2010 May;5(3):359-373. doi: 10.1586/eem.10.2.
Subclinical thyroid dysfunction occurs when peripheral thyroid hormone levels are within the normal laboratory reference range and the serum thyroid-stimulating hormone (TSH or thyrotropin) level is greater than normal (subclinical hypothyroidism) or less than normal (subclinical hyperthyroidism; TSH normal laboratory reference range: 0.3-5.0 mIU/l). For patients with subclinical hypothyroidism (serum TSH levels >10 mIU/l), thyroxine therapy is prescribed if other causes of TSH elevation and transient conditions have been excluded. For serum TSH levels between 5.0 and 10.0 mIU/l, selective therapy should be considered. For patients with sustained subclinical hyperthyroidism (serum TSH levels <0.1 mIU/l), therapy is recommended, especially in older patients. Observation or selective therapy should be considered for patients with serum TSH levels between 0.1 and 0.3 mIU/l.
当外周甲状腺激素水平在实验室正常参考范围内，而血清促甲状腺激素（TSH或促甲状腺素）水平高于正常（亚临床甲状腺功能减退）或低于正常（亚临床甲状腺功能亢进；TSH正常实验室参考范围：0.3 - 5.0 mIU/l）时，就会发生亚临床甲状腺功能障碍。对于亚临床甲状腺功能减退患者（血清TSH水平>10 mIU/l），如果排除了TSH升高的其他原因和短暂性情况，则应给予甲状腺素治疗。对于血清TSH水平在5.0至10.0 mIU/l之间的患者，应考虑选择性治疗。对于持续性亚临床甲状腺功能亢进患者（血清TSH水平<0.1 mIU/l），建议进行治疗，尤其是老年患者。对于血清TSH水平在0.1至0.3 mIU/l之间的患者，应考虑观察或选择性治疗。
