1 Department of Medicine, Vidant Medical Center, Greenville, USA.
2 Department of Medicine, Our Lady of the Lake Regional Medical Center, Baton Rouge, USA.
Eur J Prev Cardiol. 2019 May;26(7):746-749. doi: 10.1177/2047487318816387. Epub 2018 Nov 30.
Numerous studies have investigated use of acetylsalicylic acid (ASA) for prevention of cardiovascular deaths. The vast majority of the work in this area has focused on secondary prevention. However, underuse of ASA still remains a major issue. Fewer studies have investigated the impact of ASA on primary prevention of cardiovascular death. A meta-analysis of individual participant data from six randomized studies, published in 2009, showed decrease in serious vascular events but at the cost of causing increased bleeding and hemorrhagic stroke. Recent studies have raised a number of key questions regarding the benefits and risks of using ASA for primary prevention.
许多研究都调查了使用乙酰水杨酸（ASA）预防心血管死亡的情况。这方面的绝大多数工作都集中在二级预防上。然而，ASA 的使用率仍然是一个主要问题。研究 ASA 对心血管死亡一级预防影响的研究较少。2009 年发表的一项来自六项随机研究的个体参与者数据的荟萃分析显示，严重血管事件减少，但代价是出血和出血性中风增加。最近的研究提出了一些关于使用 ASA 进行一级预防的益处和风险的关键问题。
