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贝利尤单抗治疗系统性红斑狼疮相关难治性机化性肺炎:一例报告

Belimumab in refractory organizing pneumonia associated with systemic lupus erythematosus: a case report.

作者信息

Giménez Ai Rebollo, Pastrana D Bellido, Huaranga M A Ramírez, Izquierdo J Ros, Cabrera B, García A Núñez, Rodríguez C C Ramos

机构信息

1 Department of Rheumatology, Ciudad Real University General Hospital, Ciudad Real, Spain.

2 Department of Internal Medicine, Ciudad Real University General Hospital, Ciudad Real, Spain.

出版信息

Lupus. 2019 Apr;28(4):565-568. doi: 10.1177/0961203319835320. Epub 2019 Mar 12.

DOI:10.1177/0961203319835320
PMID:30862250
Abstract

Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. This report presents the case of a 56-year-old woman with systemic lupus erythematosus who was diagnosed with an organizing pneumonia and showed a poor response to steroid and azathioprine treatment. We considered the use of belimumab, which resulted in excellent clinical and radiological outcomes.

摘要

机化性肺炎是一种肺部炎症性疾病,具有多种多样的临床、影像学和病理表现形式。机化性肺炎可以是特发性的,也可以继发于其他疾病。皮质类固醇治疗通常是一线治疗方法,在大多数情况下可使病情出现临床改善。本报告介绍了一名56岁系统性红斑狼疮女性患者的病例,该患者被诊断为机化性肺炎,对类固醇和硫唑嘌呤治疗反应不佳。我们考虑使用贝利尤单抗,结果取得了出色的临床和影像学效果。

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