Division of Rheumatology, Center for Rheumatic Diseases, Seirei Yokohama Hospital, Yokohama, Kanagawa, Japan.
Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan.
Mod Rheumatol Case Rep. 2024 Jul 8;8(2):264-266. doi: 10.1093/mrcr/rxae010.
Lupus protein-losing enteropathy (LUPLE) is a rare condition in patients with systemic lupus erythematosus (SLE). Since the causes and exact pathological mechanism have not been elucidated, appropriate treatment has not been determined. Here, we report the case of a 69-year-old woman with systemic lupus erythematosus who developed LUPLE which was successfully treated with belimumab without an increase in glucocorticoid dose. This case suggests that belimumab monotherapy may be a treatment option for LUPLE.
狼疮蛋白丢失性肠病（LUPLE）是系统性红斑狼疮（SLE）患者的一种罕见病症。由于其病因和确切的病理机制尚未阐明，因此尚未确定合适的治疗方法。在这里，我们报告了一例 69 岁系统性红斑狼疮女性患者发生 LUPLE 的病例，该患者使用贝利尤单抗治疗获得成功，且未增加糖皮质激素剂量。该病例提示贝利尤单抗单药治疗可能是 LUPLE 的一种治疗选择。
