Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia; Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, Melbourne, VIC, Australia.
Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, St Albans, VIC, Australia; Institute for Health and Sport, Victoria University, VIC, Australia.
EBioMedicine. 2019 Jan;39:603-611. doi: 10.1016/j.ebiom.2018.11.051. Epub 2018 Dec 3.
Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreement and contradiction within it. This review explores the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells, in the areas of plastic adherence, differentiation capacity, proliferation, and cellular homing. We also review the implications for future use of COP cells in clinical practice, particularly in the area of regenerative medicine and the treatment and assessment of musculoskeletal disease.
循环成骨前体细胞（COP）是最近发现的一类循环祖细胞，它们不仅具有形成骨的能力，还具有形成其他间充质组织的能力。目前有一小部分但不断增长的文献探讨了这些细胞，但其中存在大量的分歧和矛盾。本综述探讨了这些细胞的起源和生物学特征，包括用于从外周血中分离这些细胞的鉴定策略。它还检查了这些细胞在塑料黏附、分化能力、增殖和细胞归巢等方面的体外和体内行为的现有知识。我们还回顾了 COP 细胞在临床实践中的未来应用的意义，特别是在再生医学和肌肉骨骼疾病的治疗和评估领域。
