Jo In Young, Yeo Seung-Gu
Department of Radiation Oncology, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital, Cheonan, Republic of Korea,
Onco Targets Ther. 2019 Feb 18;12:1359-1364. doi: 10.2147/OTT.S189858. eCollection 2019.
The incidence of large cell neuroendocrine carcinoma (LCNEC) of the lung is rare, and the treatment methods and prognosis for such patients are still subjects of debate. We report a case of a 78-year-old male LCNEC patient for whom stereotactic body radiation therapy was performed. A four-dimensional computed tomography scan was used for simulation, and radiotherapy was planned using the volumetrically modulated arc technique. A total of 55 Gy was delivered in five daily fractions. The treatment was safely completed, and the patient did not report any discomfort. The only side-effect was an intermittent cough. Currently, the patient has received 18 months of outpatient follow-up care with no evidence of disease. In conclusion, stereotactic body radiation therapy can be a valuable treatment option for early stage LCNEC.
肺大细胞神经内分泌癌（LCNEC）的发病率很低，此类患者的治疗方法和预后仍是争论的话题。我们报告一例78岁男性LCNEC患者，对其实施了立体定向体部放射治疗。使用四维计算机断层扫描进行模拟，并采用容积调强弧形技术进行放射治疗计划。每天分5次共给予55 Gy的剂量。治疗安全完成，患者未报告任何不适。唯一的副作用是间歇性咳嗽。目前，该患者已接受18个月的门诊随访，无疾病迹象。总之，立体定向体部放射治疗对于早期LCNEC可能是一种有价值的治疗选择。
