Świdrowska-Jaros Joanna, Smolewska Elżbieta
Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Poland.
Cent Eur J Immunol. 2018;43(3):325-330. doi: 10.5114/ceji.2018.80052. Epub 2018 Oct 30.
Angiogenesis is the complex process of creating new capillaries from preexisting blood vessels due to hypoxemia, injury or inflammation of the tissues. Numerous cytokines and cell mediators have been identified to induce and stimulate angiogenesis, but vascular endothelial growth factor (VEGF) is a key regulator. The role of proangiogenic factors in the pathogenesis of chronic arthritis is currently a subject of intensive investigations in adult patients with rheumatoid arthritis (RA) and, to a limited extent, in children with juvenile idiopathic arthritis (JIA). Recent studies has shown a significant correlation between proangiogenic marker concentrations and the severity of inflammation in either RA or JIA patients. The serum neovascularization markers correlate with the power Doppler ultrasound image of the inflamed joint and hypertrophic synovium, which may be connected with the disease activity. The aim of this paper is to describe the state of the art on the important role of angiogenesis in adult and childhood rheumatoid arthritis.
血管生成是由于组织缺氧、损伤或炎症，从已有的血管中生成新毛细血管的复杂过程。已确定多种细胞因子和细胞介质可诱导和刺激血管生成，但血管内皮生长因子（VEGF）是关键调节因子。促血管生成因子在慢性关节炎发病机制中的作用目前是成年类风湿关节炎（RA）患者深入研究的课题，在幼年特发性关节炎（JIA）儿童中也有一定程度的研究。最近的研究表明，促血管生成标志物浓度与RA或JIA患者的炎症严重程度之间存在显著相关性。血清新血管生成标志物与炎症关节和肥厚滑膜的功率多普勒超声图像相关，这可能与疾病活动有关。本文旨在描述血管生成在成人和儿童类风湿关节炎中的重要作用的研究现状。
