Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam University Medical Center, Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Int J Mol Sci. 2022 Jun 25;23(13):7071. doi: 10.3390/ijms23137071.
Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event for the development of the proliferative synovium. This process is markedly intensified in patients with prolonged disease duration, high disease activity, disease severity, and significant inflammatory cell infiltration. Angiogenesis is therefore an interesting target for the development of new therapeutic approaches as well as disease monitoring strategies in RA. To this end, nuclear imaging modalities represent valuable non-invasive tools that can selectively target molecular markers of angiogenesis and accurately and quantitatively track molecular changes in multiple joints simultaneously. This systematic review summarizes the imaging markers used for single photon emission computed tomography (SPECT) and/or positron emission tomography (PET) approaches, targeting pathways and mediators involved in synovial neo-angiogenesis in RA.
广泛的血管生成是类风湿关节炎（RA）滑膜组织的一个特征，从疾病的早期阶段开始，并且是增生性滑膜发展的关键事件。在疾病持续时间长、疾病活动度高、疾病严重程度和炎症细胞浸润显著的患者中，这一过程明显加剧。因此，血管生成是开发新的治疗方法以及 RA 疾病监测策略的一个有趣的靶点。为此，核成像方式代表了有价值的非侵入性工具，可以选择性地针对血管生成的分子标记物，并准确和定量地同时跟踪多个关节中的分子变化。本系统综述总结了用于单光子发射计算机断层扫描（SPECT）和/或正电子发射断层扫描（PET）方法的成像标记物，这些方法针对 RA 滑膜中新血管生成涉及的途径和介质。
