Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Clin Auton Res. 2019 Dec;29(6):595-601. doi: 10.1007/s10286-019-00602-2. Epub 2019 Mar 12.
Drooling is a common symptom of neurodegenerative diseases. We aimed to explore the frequency of drooling and its relationship to clinical features in a relatively large cohort of Chinese patients with multiple system atrophy (MSA).
We conducted a cross-sectional survey of 143 patients with MSA. Patients with drooling were identified as those with a score ≥ 1 on item 6 of the Unified Parkinson's Disease Rating Scale. Additional scales were used to rate daily functionality, neurologic and cognitive capabilities, levels of anxiety and depression, and sleep quality. These results were compared between patients with and without drooling.
The frequency of drooling in this cohort was 59.4% (85/143). Drooling was associated with significantly poorer scores on the Unified MSA Rating Scale (subscore I, subscore II, subscore IV, total score), Pittsburgh Sleep Quality Index, Hamilton Depression Scale, Hamilton Anxiety Scale, and Mini-Mental State Examination. After adjusting for confounders, regression analysis identified two independent risk factors for drooling: parkinsonism-associated MSA (OR 2.54, 95% CI 1.15-5.65) and hypomimia (OR 3.18, 95% CI 1.32-7.68).
Drooling is relatively common among Chinese MSA patients, and parkinsonism-associated MSA and hypomimia appear to be independent risk factors for drooling. The severity of this symptom correlates with the presence of severe motor symptoms, anxiety, depression, and sleep disorders.
流涎是神经退行性疾病的常见症状。我们旨在探索流涎的频率及其与中国较大队列多系统萎缩（MSA）患者临床特征的关系。
我们对 143 例 MSA 患者进行了横断面调查。流涎患者的定义为统一帕金森病评定量表第 6 项评分≥1。还使用了其他量表来评估日常功能、神经认知能力、焦虑和抑郁程度以及睡眠质量。比较了有流涎和无流涎患者的这些结果。
该队列中流涎的频率为 59.4%（85/143）。流涎与统一 MSA 评定量表评分（子量表 I、子量表 II、子量表 IV、总分）、匹兹堡睡眠质量指数、汉密尔顿抑郁量表、汉密尔顿焦虑量表和简易精神状态检查显著降低有关。在调整混杂因素后，回归分析确定了流涎的两个独立危险因素：帕金森病相关 MSA（OR 2.54，95%CI 1.15-5.65）和运动不能（OR 3.18，95%CI 1.32-7.68）。
流涎在中国 MSA 患者中较为常见，帕金森病相关 MSA 和运动不能似乎是流涎的独立危险因素。该症状的严重程度与严重运动症状、焦虑、抑郁和睡眠障碍的存在相关。
