Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Lancet Neurol. 2015 Jun;14(6):625-39. doi: 10.1016/S1474-4422(15)00007-1.
Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's disease has increased substantially in the past decade. The entire gastrointestinal tract is affected in these patients, causing complications that range from oral issues, including drooling and swallowing problems, to delays in gastric emptying and constipation. Additionally, small intestinal bacterial overgrowth and Helicobacter pylori infection affect motor fluctuations by interfering with the absorption of antiparkinsonian drugs. The multifaceted role of the gastrointestinal system in Parkinson's disease necessitates a specific and detailed assessment and treatment plan. The presence of pervasive α-synuclein deposition in the gastrointestinal tract strongly implicates this system in the pathogenesis of Parkinson's disease. Future studies elucidating the role of the gastrointestinal tract in the pathological progression of Parkinson's disease might hold potential for early disease detection and development of neuroprotective approaches.
在过去的十年中，我们对帕金森病患者胃肠道系统功能障碍的理解有了很大的提高。这些患者的整个胃肠道都受到了影响，导致了从口腔问题（包括流涎和吞咽问题）到胃排空延迟和便秘等各种并发症。此外，小肠细菌过度生长和幽门螺杆菌感染通过干扰抗帕金森病药物的吸收而影响运动波动。胃肠道系统在帕金森病中的多方面作用需要进行具体和详细的评估和治疗计划。在胃肠道中广泛存在α-突触核蛋白沉积强烈表明该系统与帕金森病的发病机制有关。未来阐明胃肠道在帕金森病病理进展中的作用的研究可能为早期疾病检测和神经保护方法的发展提供潜力。
