Stroke Unit, IRCCS Mondino Foundation, Pavia, Italy.
Diagnostic Imaging Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Ann Neurol. 2019 Jun;85(6):943-947. doi: 10.1002/ana.25466. Epub 2019 Apr 3.
We investigated whether computed tomography (CT) perfusion can identify intracerebral hemorrhage patients at high risk of hematoma growth (HG). A total of 155 subjects underwent CT perfusion on admission. Variables associated with log-transformed absolute HG were explored with multivariable linear regression. Perihematomal cerebral blood volume (CBV) was inversely associated with HG (B = -0.20; p < 0.001), independently from blood pressure, hematoma volume, and other confounders. This association was not dose dependent, and only very low CBV (<1.4 ml/100 g) was significantly associated with HG (B = 0.25; p < 0.001). In conclusion, reduced perihematomal CBV is associated with HG, suggesting a potential role of the perihematomal region in the pathophysiology of hematoma enlargement. ANN NEUROL 2019;85:943-947.
我们研究了计算机断层扫描（CT）灌注是否可以识别颅内出血患者血肿增大（HG）的高风险。共有 155 名受试者在入院时接受 CT 灌注检查。使用多变量线性回归探讨与对数值转换的绝对 HG 相关的变量。血肿周围脑血容量（CBV）与 HG 呈负相关（B=-0.20；p<0.001），与血压、血肿量和其他混杂因素独立相关。这种相关性不是剂量依赖性的，只有非常低的 CBV（<1.4ml/100g）与 HG 显著相关（B=0.25；p<0.001）。总之，血肿周围 CBV 降低与 HG 相关，提示血肿扩大的病理生理学中血肿周围区域可能起作用。神经病学年鉴 2019；85：943-947。
