Silva Tatiane Maria da, Soares Valéria Martins, Ramos Mariana Gontijo, Santos Adriana Dos
. Faculdade de Biomedicina, Universidade da Fundação Mineira de Educação e Cultura - FUMEC - Belo Horizonte (MG) Brasil.
. Setor de Microbiologia, Laboratório do Hospital Júlia Kubitschek, Fundação Hospitalar do Estado de Minas Gerais - FHEMIG - Belo Horizonte (MG) Brasil.
J Bras Pneumol. 2019 Mar 11;45(2):e20170451. doi: 10.1590/1806-3713/e20170451.
Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the Júlia Kubitschek Hospital, which is operated by the Hospital Foundation of the State of Minas Gerais, in the city of Belo Horizonte, Brazil. This was a retrospective study comparing the Xpert MTB/RIF test results with those of standard culture for Mycobacterium tuberculosis and phenotypic susceptibility tests. Although the Xpert MTB/RIF test showed high accuracy for the detection of M. tuberculosis and its resistance to rifampin, attention must be given to the clinical status of the patient, in relation to the test results, as well as to the limitations of molecular tests.
结核病仍然是全球主要的公共卫生问题。本研究的目的是，利用从巴西贝洛奥里藏特市由米纳斯吉拉斯州医院基金会运营的胡利亚·库比契克医院接受治疗的患者获取的肺部样本，评估Xpert MTB/RIF结核病快速分子检测的准确性。这是一项回顾性研究，将Xpert MTB/RIF检测结果与结核分枝杆菌的标准培养结果及表型药敏试验结果进行比较。尽管Xpert MTB/RIF检测在检测结核分枝杆菌及其对利福平的耐药性方面显示出很高的准确性，但必须关注患者的临床状况与检测结果的关系，以及分子检测的局限性。
