Casela Marilda, Cerqueira Silvânia Maria Andrade, Casela Thais de Oliveira, Pereira Mariana Araújo, Santos Samanta Queiroz Dos, Pozo Franco Andres Del, Freire Songeli Menezes, Matos Eliana Dias
Hospital Especializado Octávio Mangabeira, Secretaria de Saúde do Estado da Bahia, Salvador, BA, Brasil.
Universidade Federal de Alagoas, Maceió, AL, Brazil.
J Bras Pneumol. 2018 Apr;44(2):112-117. doi: 10.1590/s1806-37562017000000201.
To evaluate the impact of the use of the molecular test for Mycobacterium tuberculosis and its resistance to rifampin (Xpert MTB/RIF), under routine conditions, at a referral hospital in the Brazilian state of Bahia.
This was a descriptive study using the database of the Mycobacteriology Laboratory of the Octávio Mangabeira Specialized Hospital, in the city of Salvador, and georeferencing software. We evaluated 3,877 sputum samples collected from symptomatic respiratory patients, under routine conditions, between June of 2014 and March of 2015. All of the samples were submitted to sputum smear microscopy and the Xpert MTB/RIF test. Patients were stratified by gender, age, and geolocation.
Among the 3,877 sputum samples evaluated, the Xpert MTB/RIF test detected M. tuberculosis in 678 (17.5%), of which 60 (8.8%) showed resistance to rifampin. The Xpert MTB/RIF test detected M. tuberculosis in 254 patients who tested negative for sputum smear microscopy, thus increasing the diagnostic power by 59.9%.
The use of the Xpert MTB/RIF test, under routine conditions, significantly increased the detection of cases of tuberculosis among sputum smear-negative patients.
评估在巴西巴伊亚州一家转诊医院的常规条件下，使用结核分枝杆菌及其对利福平耐药性的分子检测方法（Xpert MTB/RIF）的影响。
这是一项描述性研究，使用了位于萨尔瓦多市的奥克塔维奥·曼加贝拉专科医院分枝杆菌实验室的数据库以及地理定位软件。我们评估了2014年6月至2015年3月期间在常规条件下从有症状的呼吸道患者中采集的3877份痰标本。所有标本均进行痰涂片显微镜检查和Xpert MTB/RIF检测。患者按性别、年龄和地理位置进行分层。
在评估的3877份痰标本中，Xpert MTB/RIF检测在678份标本中检测到结核分枝杆菌（17.5%），其中60份（8.8%）对利福平耐药。Xpert MTB/RIF检测在254例痰涂片显微镜检查呈阴性的患者中检测到结核分枝杆菌，从而使诊断能力提高了59.9%。
在常规条件下使用Xpert MTB/RIF检测，显著提高了痰涂片阴性患者中结核病病例的检出率。
