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Targeting a fibrotic bottleneck may provide an opening in the treatment of LUTS.

作者信息

Ricke William A, Bruskewitz Reginald C, Liu Teresa T

机构信息

George M. O'Brien Center for Benign Urologic Research and Department of Urology, University of Wisconsin-Madison , Madison, Wisconsin.

出版信息

Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1091-F1093. doi: 10.1152/ajprenal.00102.2019. Epub 2019 Mar 13.

DOI:10.1152/ajprenal.00102.2019
PMID:30864837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6620586/
Abstract
摘要

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本文引用的文献

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Consequences of interleukin 1β-triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4 infiltration mimics human proliferative inflammatory atrophy.白细胞介素1β引发的小鼠前列腺慢性炎症的后果：与CD4浸润延长相关的结构改变模拟人类增殖性炎性萎缩。
Prostate. 2019 May;79(7):732-745. doi: 10.1002/pros.23784. Epub 2019 Mar 22.
2
Uropathogenic Escherichia coli-induced fibrosis, leading to lower urinary tract symptoms, is associated with type 2 cytokine signaling.尿路致病性大肠杆菌引起的纤维化，导致下尿路症状，与 2 型细胞因子信号有关。
Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F682-F692. doi: 10.1152/ajprenal.00222.2018. Epub 2019 Jan 9.
3
In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms.人尿代谢组的深入表征与验证揭示了下尿路症状的新型代谢特征。
Sci Rep. 2016 Aug 9;6:30869. doi: 10.1038/srep30869.
4
The role of prostate inflammation and fibrosis in lower urinary tract symptoms.前列腺炎症和纤维化在下尿路症状中的作用。
Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F817-F821. doi: 10.1152/ajprenal.00602.2015. Epub 2016 Jul 20.
5
Characterization of fibrillar collagens and extracellular matrix of glandular benign prostatic hyperplasia nodules.腺性良性前列腺增生结节的纤维状胶原蛋白和细胞外基质的特征分析
PLoS One. 2014 Oct 2;9(10):e109102. doi: 10.1371/journal.pone.0109102. eCollection 2014.
6
Prostatic fibrosis, lower urinary tract symptoms, and BPH.前列腺纤维化、下尿路症状和良性前列腺增生症。
Nat Rev Urol. 2013 Sep;10(9):546-50. doi: 10.1038/nrurol.2013.149. Epub 2013 Jul 16.
7
Sex steroid receptor expression and localization in benign prostatic hyperplasia varies with tissue compartment.在良性前列腺增生中，性类固醇受体的表达和定位随组织隔室而变化。
Differentiation. 2013 Apr-Jun;85(4-5):140-9. doi: 10.1016/j.diff.2013.02.006. Epub 2013 Jun 20.
8
Male lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH).男性下尿路症状（LUTS）和良性前列腺增生（BPH）。
Med Clin North Am. 2011 Jan;95(1):87-100. doi: 10.1016/j.mcna.2010.08.013.
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Uropathogenic Escherichia coli induces chronic pelvic pain.尿路致病性大肠杆菌可引起慢性盆腔痛。
Infect Immun. 2011 Feb;79(2):628-35. doi: 10.1128/IAI.00910-10. Epub 2010 Nov 15.
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