迈向干细胞分类。
Towards a classification of stem cells.
机构信息
Institut d'Histoire et Philosophie des Sciences et des Techniques, Université Paris I Panthéon-Sorbonne, Paris, France.
Département d'Hématologie, Institut de Cancérologie Gustave Roussy, Villejuif, France.
出版信息
Elife. 2019 Mar 13;8:e46563. doi: 10.7554/eLife.46563.
Abstract
The characteristic properties of stem cells - notably their ability to self-renew and to differentiate - have meant that they have traditionally been viewed as distinct from most other types of cells. However, recent research has blurred the line between stem cells and other cells by showing that the former display a range of behaviors in different tissues and at different stages of development. Here, we use the tools of metaphysics to describe a classification scheme for stem cells, and to highlight what their inherent diversity means for cancer treatment.
摘要
干细胞的特征属性 - 特别是它们的自我更新和分化能力 - 意味着它们传统上被视为与大多数其他类型的细胞不同。然而，最近的研究通过表明前者在不同组织和不同发育阶段表现出一系列行为，模糊了干细胞和其他细胞之间的界限。在这里，我们使用形而上学的工具来描述干细胞的分类方案，并强调它们内在的多样性对癌症治疗的意义。
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Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention.干细胞分裂、体细胞突变、癌症病因学与癌症预防。
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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions.癌症病因。组织间癌症风险的差异可由干细胞分裂次数来解释。
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