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实体器官移植受者中由罗氏梅迪科真菌引起的暗色丝孢霉病:两例报告及文献综述

Phaeohyphomycosis caused by Medicopsis romeroi in solid organ transplant recipients: Report of two cases and comprehensive review of the literature.

作者信息

Los-Arcos Ibai, Royuela Meritxell, Martín-Gómez M Teresa, Alastruey-Izquierdo Ana, Sellarès Joana, Perelló Manel, Castells Lluís, Dopazo Cristina, Gavaldà Joan, Len Oscar

机构信息

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Departament of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Transpl Infect Dis. 2019 Jun;21(3):e13072. doi: 10.1111/tid.13072. Epub 2019 Mar 27.

DOI:10.1111/tid.13072
PMID:30865352
Abstract

Medicopsis romeroi is a melanized coelomycetous fungus, mainly found in tropical and subtropical regions and an uncommon cause of infection in solid organ transplant (SOT) recipients. We describe two cases of SOT recipients diagnosed with phaeohyphomycosis due to M romeroi and provide a comprehensive literature review. These infections should be considered in patients native to tropical countries with a localized skin and soft tissue infection. Sequencing is needed for accurate identification of uncommon melanized fungi. Surgical treatment is recommended to cure the infection and co-adjunctive oral antifungals should be considered.

摘要

罗氏拟茎点霉是一种黑化的腔孢纲真菌,主要见于热带和亚热带地区,是实体器官移植(SOT)受者中罕见的感染原因。我们描述了两例被诊断为罗氏拟茎点霉所致暗色丝孢霉病的SOT受者病例,并提供了全面的文献综述。对于来自热带国家且患有局部皮肤和软组织感染的患者,应考虑这些感染。对于罕见的黑化真菌,需要进行测序以准确鉴定。建议采用手术治疗来治愈感染,同时应考虑辅助口服抗真菌药物。

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