Thamotharan Nishantan, P Vengatachalapathy, Kumaravel Arthipriya, Sundaram Murugan, Swaminathan Adikrishnan
Dermatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.
Dermatology, Venereology, and Leprosy, Government Medical College and Hospital, Thiruvallur, Chennai, IND.
Cureus. 2025 Apr 12;17(4):e82124. doi: 10.7759/cureus.82124. eCollection 2025 Apr.
Phaeohyphomycosis is a rare subcutaneous fungal infection caused by dematiaceous fungi, commonly presenting as cystic swellings or subcutaneous abscesses. These infections predominantly affect immunocompromised individuals, including transplant recipients, due to impaired cell-mediated immunity, which plays a crucial role in fungal defense. We report three cases of post-renal transplant phaeohyphomycosis, presenting within six to 12 months post transplant. The diagnosis was based on clinical features and potassium hydroxide (KOH) mount findings showing pigmented septate hyphae. Histopathological examination of skin biopsy with Gomori methenamine silver stain confirmed pigmented hyphae, and culture identified . Treatment included surgical excision of lesions combined with oral itraconazole and voriconazole.
暗色丝孢霉病是一种由暗色真菌引起的罕见皮下真菌感染，通常表现为囊性肿胀或皮下脓肿。由于细胞介导的免疫受损，这些感染主要影响免疫功能低下的个体，包括移植受者，而细胞介导的免疫在真菌防御中起关键作用。我们报告了3例肾移植后暗色丝孢霉病病例，均在移植后6至12个月内发病。诊断基于临床特征以及氢氧化钾（KOH）涂片检查发现有色素分隔菌丝。经Gomori六胺银染色的皮肤活检组织病理学检查证实有色素菌丝，培养鉴定出……治疗包括手术切除病灶，并联合口服伊曲康唑和伏立康唑。
