Alia Erisa, Feit Eric J, Levitt Jacob Oren
Department of Dermatology, Mount Sinai Hospital, New York City, New York.
Dermatol Online J. 2019 Feb 15;25(2):13030/qt4hb7q330.
Pretibial myxedema or thyroid dermopathy constitutes dermal deposition of mucin, primarily hyaluronic acid and chondroitin sulfate. It is a manifestation of autoimmune thyroiditis, seen more in Graves disease than in Hashimoto thyroiditis. The time delay from treatment of hyperthyroidism to appearance of localized myxedema varies from one month to 16 years (mean 5.13 years). Despite a variety of therapeutic options, failure and relapse rates are high. Therapeutic options reported in the literature include compression, topical and intralesional corticosteroids, oral pentoxifylline, octreotide, rituximab, plasmapheresis, and high-dose intravenous immunoglobulin. We share our experience in two patients who were treated with electrosurgical debulking of selected longstanding myxedematous lesions, with one positive result and one negative result.
胫前黏液性水肿或甲状腺皮肤病表现为黏蛋白在皮肤沉积，主要为透明质酸和硫酸软骨素。它是自身免疫性甲状腺炎的一种表现，在格雷夫斯病中比在桥本甲状腺炎中更常见。从甲亢治疗到局部黏液性水肿出现的时间间隔从1个月到16年不等（平均5.13年）。尽管有多种治疗选择，但失败率和复发率都很高。文献报道的治疗方法包括压迫、局部和病灶内注射皮质类固醇、口服己酮可可碱、奥曲肽、利妥昔单抗、血浆置换和大剂量静脉注射免疫球蛋白。我们分享了对两名患者的治疗经验，这两名患者接受了对选定的长期黏液性水肿病变进行电外科减容治疗，结果一正一负。
