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抑郁症患者催乳素对促甲状腺激素释放激素的反应

Prolactin response to TRH in depression.

作者信息

Zis A P, Albala A A, Haskett R F, Carroll B J, Lohr N E

出版信息

J Psychiatr Res. 1986;20(1):77-82. doi: 10.1016/0022-3956(86)90025-7.

DOI:10.1016/0022-3956(86)90025-7
PMID:3086543
Abstract

We studied the prolactin response to TRH in 53 unmedicated psychiatric inpatients. The prolactin response of females was significantly greater than the response of male subjects. There was no significant difference in the prolactin response to TRH between depressed patients and those with other psychiatric diagnoses. There was no significant relationship between the prolactin response to TRH and the severity of depression, the TSH response to TRH or the resistance to suppression of cortisol secretion by dexamethasone.

摘要

我们研究了53名未接受药物治疗的精神科住院患者对促甲状腺激素释放激素(TRH)的催乳素反应。女性的催乳素反应显著大于男性受试者的反应。抑郁症患者与其他精神科诊断患者对TRH的催乳素反应无显著差异。对TRH的催乳素反应与抑郁症严重程度、对TRH的促甲状腺激素反应或地塞米松对皮质醇分泌抑制的抵抗之间无显著关系。

相似文献

1
Prolactin response to TRH in depression.抑郁症患者催乳素对促甲状腺激素释放激素的反应
J Psychiatr Res. 1986;20(1):77-82. doi: 10.1016/0022-3956(86)90025-7.
2
The TRH test during dopamine receptor blockade in depressed patients.抑郁症患者多巴胺受体阻断期间的促甲状腺激素释放激素试验。
Psychoneuroendocrinology. 1986;11(3):327-36. doi: 10.1016/0306-4530(86)90018-1.
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TRH tests with analyses of TSH, prolactin, and GH responses in subtypes of patients with major depressive disorders.对重度抑郁症患者亚型进行促甲状腺激素释放激素测试,并分析促甲状腺激素、催乳素和生长激素的反应。
Acta Psychiatr Scand. 1986 May;73(5):549-58. doi: 10.1111/j.1600-0447.1986.tb02724.x.
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TRH-induced prolactin release is blunted in females with endogenous unipolar major depression.在患有内源性单相重度抑郁症的女性中,促甲状腺激素释放激素诱导的催乳素释放受到抑制。
Psychiatry Res. 1984 Aug;12(4):321-31. doi: 10.1016/0165-1781(84)90048-9.
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Lack of effect of deflazacort, a novel glucocorticoid, on basal and TRH-stimulated prolactin and thyrotropin levels in healthy subjects.新型糖皮质激素地夫可特对健康受试者基础及促甲状腺激素释放激素刺激的催乳素和促甲状腺激素水平无影响。
Eur J Clin Pharmacol. 1985;29(1):123-5. doi: 10.1007/BF00547381.
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Desensitization of rat anterior pituitary gland to thyrotrophin releasing hormone.大鼠垂体前叶对促甲状腺激素释放激素的脱敏作用。
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The effect of apomorphine on basal and TRH stimulated release of thyrotrophin and prolactin in man.阿扑吗啡对人体促甲状腺激素和催乳素基础分泌及促甲状腺激素释放激素刺激分泌的影响。
Acta Endocrinol (Copenh). 1975 Oct;80(2):220-9. doi: 10.1530/acta.0.0800220.
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Blunted TSH and unaltered PRL responses to TRH following repeated administration of TRH in neurologic patients: a replication of neuroendocrine features of major depression.在神经系统疾病患者中重复给予促甲状腺激素释放激素(TRH)后,促甲状腺激素(TSH)反应迟钝,而催乳素(PRL)对TRH的反应未改变:重度抑郁症神经内分泌特征的再现。
Biol Psychiatry. 1993 Feb 15;33(4):277-83. doi: 10.1016/0006-3223(93)90295-o.
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Dexamethasone suppression and multiple hormonal responses (TSH, prolactin and growth hormone) to TRH in some psychiatric disorders.某些精神疾病中地塞米松抑制及对促甲状腺激素释放激素(TRH)的多种激素反应(促甲状腺激素、催乳素和生长激素)
Eur Arch Psychiatry Neurol Sci. 1985;235(1):32-7. doi: 10.1007/BF00380966.
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The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin.糖皮质激素给药对人垂体促甲状腺激素和催乳素分泌的影响。
J Clin Endocrinol Metab. 1976 Aug;43(2):338-46. doi: 10.1210/jcem-43-2-338.

引用本文的文献

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The influence of 4-week treatment with sertraline on the combined T3/TRH test in depressed patients.舍曲林治疗4周对抑郁症患者联合T3/TRH试验的影响。
Eur Arch Psychiatry Clin Neurosci. 2005 Oct;255(5):334-40. doi: 10.1007/s00406-005-0571-0. Epub 2005 Mar 5.
2
Pharmacoendocrinology of major depression.重度抑郁症的药物内分泌学
Eur Arch Psychiatry Neurol Sci. 1989;238(5-6):259-67. doi: 10.1007/BF00449807.