氯氮卓-氟西汀对自由进食大鼠食物摄入量的相互作用。
Chlordiazepoxide-fluoxetine interactions on food intake in free-feeding rats.
作者信息
Feldman R S, Smith W C
出版信息
Pharmacol Biochem Behav. 1978 Jun;8(6):749-52. doi: 10.1016/0091-3057(78)90277-0.
PMID:308664
Abstract
Chlordiazepoxide, which blocks serotonin turnover, increased food intake; and fluoxetine, a serotonin agonist, decreased food intake. Administration of combinations of the two drugs showed an antagonistic dose-dependent relationship, implicating a satiety of hunger mechanims which is mediated by serotonin.
摘要
可阻断5-羟色胺更新的氯氮卓会增加食物摄入量；而5-羟色胺激动剂氟西汀则会减少食物摄入量。两种药物联合使用显示出剂量依赖性拮抗关系，这表明存在一种由5-羟色胺介导的饥饿饱腹感机制。
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