Institute of Sports Medicine, Hannam University, Daejeon 34430, Korea.
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea.
Int J Environ Res Public Health. 2019 Mar 7;16(5):830. doi: 10.3390/ijerph16050830.
The aim of this study was to investigate the effects of resistance exercise training on hypothalamic GLP-1R levels and its related signaling mechanisms in T2DM. The animals were separated into three groups: a non-diabetic control (CON), diabetic control (DM), and diabetic with resistance exercise (DM + EXE) group. The resistance exercise training group performed ladder climbing (eight repetitions, three days per week for 12 weeks). Body weight was slightly lower in the DM + EXE group than the DM group, but difference between the groups was not significant. Food intake and glucose were significantly lower in the DM + EXE group than in the DM group. The blood insulin concentration was significantly higher and glucagon was significantly lower in the DM + EXE group. The DM + EXE group in the hypothalamus showed significant increases in GLP-1R mRNA, protein kinase A (PKA), glucose transporter 2 (GLUT2), and protein kinase B (AKT) and significant decrease in protein kinase C-iota (PKC-iota). Antioxidant enzymes and apoptosis factors were significantly improved in the DM + EXE group compared with the DM group in the hypothalamus. The results suggest that resistance exercise contributes to improvements the overall health of the brain in diabetic conditions.
本研究旨在探讨抗阻运动训练对 T2DM 患者下丘脑 GLP-1R 水平及其相关信号机制的影响。动物分为三组：非糖尿病对照组（CON）、糖尿病对照组（DM）和糖尿病加抗阻运动组（DM + EXE）。抗阻运动训练组进行爬梯训练（8 个重复，每周 3 天，共 12 周）。DM + EXE 组的体重略低于 DM 组，但组间差异无统计学意义。DM + EXE 组的食物摄入量和血糖明显低于 DM 组。DM + EXE 组的血液胰岛素浓度明显升高，胰高血糖素明显降低。DM + EXE 组在下丘脑 GLP-1R mRNA、蛋白激酶 A（PKA）、葡萄糖转运蛋白 2（GLUT2）和蛋白激酶 B（AKT）显著增加，蛋白激酶 C-iota（PKC-iota）显著减少。与 DM 组相比，DM + EXE 组在下丘脑的抗氧化酶和细胞凋亡因子显著改善。研究结果表明，抗阻运动有助于改善糖尿病患者大脑的整体健康状况。
