近年来适体发现与应用的新进展
Recent Advances in Aptamer Discovery and Applications.
机构信息
College of Science, Harbin Institute of Technology, Shenzhen 518055, China.
School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Molecules. 2019 Mar 7;24(5):941. doi: 10.3390/molecules24050941.
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment. Furthermore, aptamers play promising roles as clinical diagnostics and therapeutic agents. This review provides update on the recent advances in this rapidly progressing field of research with particular emphasis on generation of aptamers and their applications in biosensing, biotechnology and medicine. The limitations and future directions of aptamers in target specific delivery and real-time detection are also discussed.
适体是短的、单链 DNA、RNA 或合成 XNA 分子，可以通过高亲和力和特异性来开发，以与任何所需的靶标相互作用。它们已被广泛用于促进基础研究中的发现，确保食品安全和监测环境。此外，适体在临床诊断和治疗剂方面也发挥着有前途的作用。本综述提供了该快速发展的研究领域的最新进展，特别强调适体的生成及其在生物传感、生物技术和医学中的应用。还讨论了适体在靶特异性递药和实时检测中的局限性和未来方向。
Zotero 插件