Dipartimento di Ricerca Applicata e Sviluppo Tecnologico, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Present address: ASST Papa Giovanni XXIII, Bergamo, Italy.
J Exp Clin Cancer Res. 2019 Mar 12;38(1):125. doi: 10.1186/s13046-019-1123-1.
Folate receptors and transporters and one-carbon metabolism continue to be important areas of study given their essential roles in an assortment of diseases and as targets for treatment of cancer and inflammation. Reflecting this, every 2 years, the Folate Receptor Society organizes an international meeting, alternating between North America and Europe, where basic and translational scientists, clinical oncologists and rheumatologists from both academia and industry convene in an informal setting. The 7th International Symposium on Folate Receptors and Transporters was held in Sant'Alessio Siculo (ME), Taormina, Italy from 1st to 5th of October 2018, organized by Dr. Mariangela Figini from Fondazione IRCCS Istituto Nazionale dei Tumori, Milan. Following the format of previous meetings, more than 50 scientists from 9 different countries attended the 2018 meeting to share ongoing developments, discuss current research challenges and identify new avenues in basic and translational research. An important feature of this meeting was the participation of young investigators and trainees in this area, two (A. Dekhne and N. Verweij) of whom were awarded fellowships to attend this meeting as a recognition of the high scientific quality of their work. This report provides a synopsis of the highlights presented in the following sessions: Barton Kamen Lecture; Targeting one-carbon metabolism in cytosol and mitochondria; Structure and biology of the one-carbon solute transporters; Physiology and pathophysiology of folate receptors and transporters; Folate receptors for targeting tumors and inflammatory diseases; Conventional and new anti-folate drugs for treating inflammatory diseases and cancer; Imaging; Ongoing clinical trials; and Chimeric Antigen Receptor cell therapies of cancer.
叶酸受体和转运蛋白以及一碳代谢仍然是重要的研究领域，因为它们在各种疾病中起着至关重要的作用，并且是治疗癌症和炎症的靶点。反映这一点，每隔 2 年，叶酸受体协会就会组织一次国际会议，在北美和欧洲之间交替举行，来自学术界和工业界的基础和转化科学家、临床肿瘤学家和风湿病学家在一个非正式的环境中聚集在一起。第 7 届国际叶酸受体和转运蛋白研讨会于 2018 年 10 月 1 日至 5 日在意大利陶尔米纳的圣亚莱西奥西西里（ME）举行，由米兰的 IRCCS 国家肿瘤基金会的 Mariangela Figini 博士组织。按照以往会议的形式，来自 9 个不同国家的 50 多名科学家参加了 2018 年的会议，分享正在进行的研究进展，讨论当前的研究挑战，并确定基础和转化研究的新途径。本次会议的一个重要特点是该领域的年轻研究人员和受训人员的参与，其中两位（A. Dekhne 和 N. Verweij）获得了奖学金，以表彰他们工作的高科学质量。本报告概述了以下会议的重点：巴顿卡门讲座；靶向细胞质和线粒体中的一碳代谢；一碳溶质转运蛋白的结构和生物学；叶酸受体和转运蛋白的生理学和病理生理学；用于靶向肿瘤和炎症性疾病的叶酸受体；用于治疗炎症性疾病和癌症的常规和新型抗叶酸药物；成像；正在进行的临床试验；以及嵌合抗原受体细胞疗法治疗癌症。
