Chai Meihong, Wang Shihua, Chen Yuxin, Pei Xing, Zhen Xueyan
Department of Pharmacy, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, China.
School of Medicine, Xi'an Peihua University, Xi'an, Shaanxi, China.
Front Bioeng Biotechnol. 2025 Apr 25;13:1582659. doi: 10.3389/fbioe.2025.1582659. eCollection 2025.
Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, and targeted therapy, treatment efficacy is often hampered by drug resistance and systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as a promising strategy to enhance therapeutic precision, reduce adverse effects, and overcome resistance in CRC treatment. This review discusses the recent advancements in NDDS for CRC treatment, focusing on the optimization of oral drug delivery systems, the development of tumor-specific targeting strategies, and the design of intelligent delivery systems responsive to the tumor microenvironment (TME). Furthermore, we summarize current challenges in NDDS translation and explore future research directions for enhancing their clinical feasibility and therapeutic impact.
结直肠癌（CRC）仍然是一种高度异质性的恶性肿瘤，在全球范围内具有很高的发病率和死亡率。尽管在手术、化疗、免疫疗法和靶向治疗方面取得了进展，但治疗效果常常受到耐药性和全身毒性的阻碍。近年来，纳米药物递送系统（NDDS）已成为一种有前景的策略，可提高治疗的精准度、减少不良反应并克服结直肠癌治疗中的耐药性。本综述讨论了用于结直肠癌治疗的纳米药物递送系统的最新进展，重点关注口服给药系统的优化、肿瘤特异性靶向策略的开发以及对肿瘤微环境（TME）有响应的智能递送系统的设计。此外，我们总结了纳米药物递送系统转化过程中的当前挑战，并探索了增强其临床可行性和治疗效果的未来研究方向。
