Department of Physical Therapy,University of British Columbia (UBC),Vancouver.
Djavad Mowafaghian Centre for Brain Health,UBC,Vancouver.
Can J Aging. 2019 Jun;38(2):236-244. doi: 10.1017/S0714980818000582. Epub 2019 Mar 14.
ABSTRACTThis study explored the efficacy of aerobic training (AT) in mitigating white matter hyperintensity (WMH) progression and whether these changes are sex dependent. This was an exploratory analysis of a randomized controlled trial assessing the effect of AT on cognition in people with vascular cognitive impairment. Participants were randomized to a 6 month AT or usual care (control [CON]) group. A subset completed magnetic resonance imaging to quantify WMH volume. Using an analysis of covariance model, we found a significant sex × group interaction (p = .03). Over the 6 month study, AT females demonstrated greater WMH progression than CON females (p = .05). Among males, there was no significant between-group difference (p = .31). Within the AT group, males demonstrated significantly less WMH progression than females (p = .01) at 6 months. Therefore, the effects of AT on WMH progression may vary by sex; that is, AT may curtail WMH progression in males but not females.
本研究旨在探讨有氧运动（AT）在减缓脑白质高信号（WMH）进展方面的效果，以及这些变化是否存在性别依赖性。这是一项随机对照试验的探索性分析，旨在评估 AT 对血管性认知障碍患者认知的影响。参与者被随机分配到 6 个月的 AT 或常规护理（对照组 [CON]）组。一部分人完成了磁共振成像，以定量测量脑白质高信号体积。使用协方差分析模型，我们发现了性别与组别的显著交互作用（p =.03）。在 6 个月的研究期间，AT 女性的脑白质高信号进展大于 CON 女性（p =.05）。而在男性中，两组之间没有显著差异（p =.31）。在 AT 组中，男性在 6 个月时的脑白质高信号进展明显少于女性（p =.01）。因此，AT 对脑白质高信号进展的影响可能因性别而异；也就是说，AT 可能会减缓男性的脑白质高信号进展，但不会减缓女性的脑白质高信号进展。
