Tang Yanhong, Ye Wenfeng, Liu Xia, Lv Yan, Yao Changfang, Wei Jiang
Department of Gynaecology and Obstetrics, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China.
Department of Comprehensive Laboratory, The First People's Hospital of Changzhou, Changzhou, Jiangsu 213000, P.R. China.
Exp Ther Med. 2019 Mar;17(3):2123-2128. doi: 10.3892/etm.2019.7184. Epub 2019 Jan 18.
The expression of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFLT-1) in the serum of patients with pregnancy induced hypertension (PIH) syndrome and its effects on the foetus was explored. A total of 105 cases of PIH pregnant women admitted to The First People's Hospital of Changzhou from March 2015 to February 2018 were divided into 3 groups according to the severity of the patients condition. Group A (n=35) was hypertension complicating pregnancy, group B (n=46) was mild preeclampsia and group C (n=24) was severe preeclampsia. In addition, 35 healthy pregnant women were selected as the control group. VEGF and sFLT-1 levels in serum were detected by enzyme linked immunosorbent assay, and the correlations between levels of VEGF and sFLT-1, neonatal weight and Apgar score were analyzed. Compared with group A, the level of serum VEGF was lower, while the level of sFLT-1 was higher in groups B and C (P<0.05). Compared with group B, the serum VEGF level in group C decreased significantly (P<0.05), while the serum level of sFLT-1 increased significantly (P<0.05). Compared with group A, neonatal weight and Apgar score in group C was significantly lower (P<0.05). There was a positive correlation between the serum VEGF level and neonatal weight and Apgar score (r=0.435, P<0.001. r=0.357, P<0.001). There was a negative correlation between the serum sFLT-1 level and neonatal weight and Apgar score (r=-0.351, P<0.001. r=-0.422, P<0.001). Therefore, we concluded that VEGF and sFlt-1 may be involved in the occurrence and development of PIH. The decrease of serum VEGF level and the increase of sFlt-1 level may be related to the inhibited fetal growth and development, which is of great significance in the clinical detection of PIH patients.
探讨妊娠高血压综合征（PIH）患者血清中血管内皮生长因子（VEGF）和可溶性fms样酪氨酸激酶-1（sFLT-1）的表达及其对胎儿的影响。选取2015年3月至2018年2月在常州市第一人民医院收治的105例PIH孕妇，根据病情严重程度分为3组。A组（n = 35）为妊娠期高血压，B组（n = 46）为轻度子痫前期，C组（n = 24）为重度子痫前期。另外，选取35例健康孕妇作为对照组。采用酶联免疫吸附测定法检测血清中VEGF和sFLT-1水平，并分析VEGF和sFLT-1水平、新生儿体重及Apgar评分之间的相关性。与A组相比，B组和C组血清VEGF水平较低，而sFLT-1水平较高（P < 0.05）。与B组相比，C组血清VEGF水平显著降低（P < 0.05），而血清sFLT-1水平显著升高（P < 0.05）。与A组相比，C组新生儿体重和Apgar评分显著降低（P < 0.05）。血清VEGF水平与新生儿体重和Apgar评分呈正相关（r = 0.435，P < 0.001；r = 0.357，P < 0.001）。血清sFLT-1水平与新生儿体重和Apgar评分呈负相关（r = -0.351，P < 0.001；r = -0.422，P < 0.001）。因此，我们得出结论，VEGF和sFlt-1可能参与了PIH的发生发展。血清VEGF水平降低和sFlt-1水平升高可能与胎儿生长发育受抑制有关，这对PIH患者的临床检测具有重要意义。
