Cui Yan, Bai Xianan, Niu Ming, Qin Yu, Zhang Xianyu, Pang Da
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China.
Department of Urology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China.
Oncol Lett. 2019 Mar;17(3):3289-3295. doi: 10.3892/ol.2019.9961. Epub 2019 Jan 23.
The expression of AT-rich interactive domain-containing protein 1B (ARID1B) was investigated in triple-negative breast cancer (TNBC). The association between ARID1B protein expression and the prognosis of patients with TNBC was investigated. The expression of ARID1B was examined in TNBC (n=142) and adjacent normal breast tissues (n=64) using immunohistochemical staining prior to the patients receiving any treatment. Furthermore, the association between ARID1B protein expression and various clinicopathological features was analyzed, including the survival status of patients with TNBC. Of the 142 TNBC tissues, ARID1B was highly expressed in 89 (62.7%) and poorly expressed in 53 (37.3%). ARID1B expression was associated with lymph node metastasis status, histological grade and p53 expression. ARID1B expression was upregulated significantly in the nuclei of TNBC cells compared with those of normal mammary epithelial cells. This upregulation was associated with a decreased progression-free survival rate (P=0.002) and overall survival rate (P=0.003). The results of the present study indicate that significant association exists between the nuclear expression of ARID1B and adverse prognosis in TNBC. Therefore, ARID1B may be a useful prognostic biomarker in TNBC.
在三阴性乳腺癌（TNBC）中研究了富含AT的相互作用结构域蛋白1B（ARID1B）的表达。研究了ARID1B蛋白表达与TNBC患者预后之间的关联。在患者接受任何治疗之前，使用免疫组织化学染色检测了142例TNBC组织和64例邻近正常乳腺组织中ARID1B的表达。此外，分析了ARID1B蛋白表达与各种临床病理特征之间的关联，包括TNBC患者的生存状况。在142例TNBC组织中，89例（62.7%）ARID1B高表达，53例（37.3%）低表达。ARID1B表达与淋巴结转移状态、组织学分级和p53表达相关。与正常乳腺上皮细胞核相比，TNBC细胞核中ARID1B表达明显上调。这种上调与无进展生存率降低（P=0.002）和总生存率降低（P=0.003）相关。本研究结果表明，ARID1B的核表达与TNBC的不良预后之间存在显著关联。因此，ARID1B可能是TNBC中一种有用的预后生物标志物。
