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利拉鲁肽诱发的急性胃轻瘫。

Liraglutide-induced Acute Gastroparesis.

作者信息

Rai Puja, Madi Mahmoud Y, Dickstein Aaron

机构信息

Internal Medicine, Tufts Medical Center, Boston, USA.

Gastroenterology, Tufts Medical Center, Boston, USA.

出版信息

Cureus. 2018 Dec 28;10(12):e3791. doi: 10.7759/cureus.3791.

DOI:10.7759/cureus.3791
PMID:30868005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6402745/
Abstract

We describe a case of liraglutide-induced acute gastroparesis in a 52-year-old man with a history of well-controlled type 2 diabetes who presented with symptoms of gastric outlet obstruction. The patient responded markedly to conservative treatment with gastric suctioning, antiemetic and prokinetic therapy, and discontinuation of liraglutide with a resolution of his symptoms. This case highlights the importance of considering drug-induced gastroparesis as an etiology of unexplained upper abdominal pain, nausea, and early satiety, especially in the absence of mechanical obstruction.

摘要

我们描述了一例利拉鲁肽诱发的急性胃轻瘫病例,患者为一名52岁男性,有2型糖尿病病史且病情控制良好,现出现胃出口梗阻症状。该患者对胃抽吸、止吐和促动力治疗等保守治疗反应显著,停用利拉鲁肽后症状得以缓解。该病例强调了在出现不明原因的上腹痛、恶心和早饱时,尤其是在没有机械性梗阻的情况下,将药物性胃轻瘫视为病因的重要性。

相似文献

1
Liraglutide-induced Acute Gastroparesis.利拉鲁肽诱发的急性胃轻瘫。
Cureus. 2018 Dec 28;10(12):e3791. doi: 10.7759/cureus.3791.
2
Gastroparesis With the Initiation of Liraglutide: A Case Report.利拉鲁肽起始治疗引发的胃轻瘫:一例报告
Cureus. 2020 Nov 28;12(11):e11735. doi: 10.7759/cureus.11735.
3
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4
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An 8-year review of barium studies in the diagnosis of gastroparesis.一项关于钡餐检查在胃轻瘫诊断中应用的8年回顾。
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本文引用的文献

1
Diabetic Gastroparesis: Principles and Current Trends in Management.糖尿病性胃轻瘫:管理原则与当前趋势
Diabetes Ther. 2018 Jul;9(Suppl 1):1-42. doi: 10.1007/s13300-018-0454-9. Epub 2018 Jun 22.
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Gastroparesis Updates on Pathogenesis and Management.胃轻瘫:发病机制和治疗的最新进展
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Effects of GLP-1 on appetite and weight.胰高血糖素样肽-1对食欲和体重的影响。
胰高血糖素样肽-1受体激动剂的使用与接受上消化道内镜检查的无症状患者胃内残留内容物之间关联的混杂因素:一项回顾性研究
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Is it necessary to stop glucagon-like peptide-1 receptor agonists prior to endoscopic procedure? A retrospective study.在内镜检查前停用胰高血糖素样肽-1受体激动剂有必要吗?一项回顾性研究。
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Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide.低剂量利拉鲁肽诱发的疑似胃轻瘫合并胃食管反流病
Cureus. 2022 Jul 16;14(7):e26916. doi: 10.7759/cureus.26916. eCollection 2022 Jul.
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Gastroparesis With the Initiation of Liraglutide: A Case Report.利拉鲁肽起始治疗引发的胃轻瘫:一例报告
Cureus. 2020 Nov 28;12(11):e11735. doi: 10.7759/cureus.11735.
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Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.每日一次的胰高血糖素样肽-1类似物利拉鲁肽对肥胖非糖尿病成年人胃排空、血糖参数、食欲及能量代谢的影响
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Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting.胃轻瘫相关腹痛的因素:与以恶心和呕吐为主的患者对比。
Neurogastroenterol Motil. 2013 May;25(5):427-38, e300-1. doi: 10.1111/nmo.12091. Epub 2013 Feb 17.
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Diabetic gastroparesis: what we have learned and had to unlearn in the past 5 years.糖尿病性胃轻瘫:过去 5 年中我们学到和不得不摒弃的知识。
Gut. 2010 Dec;59(12):1716-26. doi: 10.1136/gut.2009.199703. Epub 2010 Sep 25.
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Treatment of patients with diabetic gastroparesis.糖尿病胃轻瘫患者的治疗。
Gastroenterol Hepatol (N Y). 2010 Jun;6(6):1-16.
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