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利拉鲁肽起始治疗引发的胃轻瘫:一例报告

Gastroparesis With the Initiation of Liraglutide: A Case Report.

作者信息

Almustanyir Sami, Alhabeeb Habeeb, AlHusseini Noara, Al Thow Mohammed

机构信息

Department of Internal Medicine, Ministry of Health, Riyadh, SAU.

Department of Internal Medicine, King Fahad Medical City, Riyadh, SAU.

出版信息

Cureus. 2020 Nov 28;12(11):e11735. doi: 10.7759/cureus.11735.

DOI:10.7759/cureus.11735
PMID:33403167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7773310/
Abstract

Gastroparesis is a syndrome that is manifested by gastrointestinal symptoms and delayed gastric emptying without evidence of mechanical obstruction. Herein, we present the case of an 18-year-old diabetic female patient who developed clinical features suggestive of gastroparesis after initial doses of liraglutide. Although rare, drug-induced gastroparesis should be contemplated in diabetic patients with a history of recent commencement of liraglutide, particularly at higher doses. Management of drug-induced gastroparesis is largely symptomatic.

摘要

胃轻瘫是一种以胃肠道症状和胃排空延迟为特征且无机械性梗阻证据的综合征。在此,我们报告一例18岁的糖尿病女性患者,在初始剂量使用利拉鲁肽后出现了提示胃轻瘫的临床特征。尽管罕见,但对于近期开始使用利拉鲁肽尤其是高剂量的糖尿病患者,应考虑药物性胃轻瘫的可能性。药物性胃轻瘫的治疗主要是对症治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/7773310/fd6a07fca929/cureus-0012-00000011735-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/7773310/fd6a07fca929/cureus-0012-00000011735-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/7773310/fd6a07fca929/cureus-0012-00000011735-i01.jpg

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2
Epidemiology and Pathophysiology of Gastroparesis.胃轻瘫的流行病学与病理生理学
Gastrointest Endosc Clin N Am. 2019 Jan;29(1):1-14. doi: 10.1016/j.giec.2018.08.010.
3
Diabetic Gastroparesis: Principles and Current Trends in Management.糖尿病性胃轻瘫:管理原则与当前趋势
对四种认知行为压力管理能力进行等级排序和分析表明,积极主动的压力管理尤为有价值。
Sci Rep. 2024 Aug 20;14(1):19224. doi: 10.1038/s41598-024-68328-4.
4
Suspected Gastroparesis With Concurrent Gastroesophageal Reflux Disease Induced by Low-Dose Liraglutide.低剂量利拉鲁肽诱发的疑似胃轻瘫合并胃食管反流病
Cureus. 2022 Jul 16;14(7):e26916. doi: 10.7759/cureus.26916. eCollection 2022 Jul.
Diabetes Ther. 2018 Jul;9(Suppl 1):1-42. doi: 10.1007/s13300-018-0454-9. Epub 2018 Jun 22.
4
Gastroparesis Updates on Pathogenesis and Management.胃轻瘫:发病机制和治疗的最新进展
Gut Liver. 2017 Sep 15;11(5):579-589. doi: 10.5009/gnl16336.
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Liraglutide for weight management: a critical review of the evidence.利拉鲁肽用于体重管理:证据的批判性综述
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