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苯唑西林治疗期间出现严重中性粒细胞减少症并伴有肝炎

Profound Neutropenia with Concomitant Hepatitis During Oxacillin Therapy.

作者信息

Miller John B, Gelber Allan C

机构信息

Rheumatology, Johns Hopkins University School of Medicine, Baltimore, USA.

出版信息

Cureus. 2019 Jan 3;11(1):e3823. doi: 10.7759/cureus.3823.

DOI:10.7759/cureus.3823
PMID:30868036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6402867/
Abstract

Beta-lactam antibiotics are widely used and generally well-tolerated. Neutropenia and hepatitis are two adverse drug reactions associated with beta-lactam therapy that are typically benign and reversible, yet have seldom been reported as simultaneous occurrences. This narrative describes these adverse drug reactions during oxacillin therapy.

摘要

β-内酰胺类抗生素广泛应用,且一般耐受性良好。中性粒细胞减少症和肝炎是与β-内酰胺治疗相关的两种药物不良反应,通常为良性且可逆,但很少有同时发生的报道。本文叙述了苯唑西林治疗期间的这些药物不良反应。

相似文献

1
Profound Neutropenia with Concomitant Hepatitis During Oxacillin Therapy.苯唑西林治疗期间出现严重中性粒细胞减少症并伴有肝炎
Cureus. 2019 Jan 3;11(1):e3823. doi: 10.7759/cureus.3823.
2
Oxacillin induced neutropenia. A case report.苯唑西林所致中性粒细胞减少症。病例报告。
Clin Orthop Relat Res. 1978 Sep(135):69-70.
3
Reversible oxacillin-associated hepatitis in a 9-month-old boy.
J Paediatr Child Health. 2008 Mar;44(3):146-8. doi: 10.1111/j.1440-1754.2007.01278.x.
4
Effect of combination of oxacillin and non-beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus.苯唑西林与非β-内酰胺类抗生素联合使用对耐甲氧西林金黄色葡萄球菌的影响。
J Antimicrob Chemother. 1994 Jun;33(6):1155-63. doi: 10.1093/jac/33.6.1155.
5
New erythromycin derivatives enhance β-lactam antibiotics against methicillin-resistant Staphylococcus aureus.新型红霉素衍生物增强β-内酰胺类抗生素对耐甲氧西林金黄色葡萄球菌的抗菌作用。
Lett Appl Microbiol. 2015 Apr;60(4):352-8. doi: 10.1111/lam.12378. Epub 2015 Jan 14.
6
Incidence of beta-lactam-induced delayed hypersensitivity and neutropenia during treatment of infective endocarditis.感染性心内膜炎治疗期间β-内酰胺类药物引起的迟发型超敏反应和中性粒细胞减少症的发生率。
Arch Intern Med. 1999 Mar 22;159(6):607-15. doi: 10.1001/archinte.159.6.607.
7
[Neutropenia from oxacillin. 3 pediatric cases].[苯唑西林所致中性粒细胞减少症。3例儿科病例]
Pediatrie. 1984 Sep;39(6):451-4.
8
Profound neutropenia caused by oxacillin.由苯唑西林引起的严重中性粒细胞减少症。
South Med J. 1977 Oct;70(10):1245-6. doi: 10.1097/00007611-197710000-00027.
9
Severe hepatitis associated with oxacillin therapy.
South Med J. 2002 Jun;95(6):650-2.
10
Full-Genome Sequencing Identifies in the Genetic Background Several Determinants That Modulate the Resistance Phenotype in Methicillin-Resistant Staphylococcus aureus Strains Carrying the Novel Gene.全基因组测序在遗传背景中鉴定出了几个决定因素,这些因素可调节携带新基因的耐甲氧西林金黄色葡萄球菌菌株的耐药表型。
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.02500-16. Print 2017 Mar.

本文引用的文献

1
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.HLA - B*5701基因型是氟氯西林所致药物性肝损伤的主要决定因素。
Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.
2
OXACILLIN--APPARENT HEMATOLOGIC AND HEPATIC TOXICITY.苯唑西林——明显的血液学及肝脏毒性。
Rocky Mt Med J. 1965 Jan;62:34-6.
3
Severe hepatitis associated with oxacillin therapy.
South Med J. 2002 Jun;95(6):650-2.
4
Inhibition of granulopoiesis in vivo and in vitro by beta-lactam antibiotics.β-内酰胺类抗生素在体内和体外对粒细胞生成的抑制作用。
J Infect Dis. 1985 Jul;152(1):90-8. doi: 10.1093/infdis/152.1.90.
5
Cloxacillin-induced neutropenia.氯唑西林诱导的中性粒细胞减少症。
J Infect Dis. 1986 Aug;154(2):372. doi: 10.1093/infdis/154.2.372.
6
Profound neutropenia caused by oxacillin.由苯唑西林引起的严重中性粒细胞减少症。
South Med J. 1977 Oct;70(10):1245-6. doi: 10.1097/00007611-197710000-00027.
7
The mechanism of oxacillin-induced neutropenia.苯唑西林诱导中性粒细胞减少的机制。
J Pediatr. 1977 Apr;90(4):668-9. doi: 10.1016/s0022-3476(77)80413-7.
8
Hepatitis associated with high-dose oxacillin therapy.与高剂量苯唑西林治疗相关的肝炎
Arch Intern Med. 1978 Jun;138(6):915-7.