Pollock A A, Berger S A, Simberkoff M S, Rahal J J
Arch Intern Med. 1978 Jun;138(6):915-7.
A prospective survey of liver function during oxacillin sodium therapy revealed five cases of drug-related abnormalities among 41 patients. In each instance, the serum transaminase level was increased from normal to greater than 100 units. The serum alkaline phosphatase level was mildly elevated and bilirubin levels remained normal. All of the patients were asymptomatic. Hepatic dysfunction was reversible on withdrawal of oxacillin therapy and substitution of a cephalosporin or clindamycin. The observed abnormalities in liver function were associated with a daily oxacillin sodium dose of greater than or equal to 12 gm as well as with heroin addiction and staphylococcal endocarditis.
一项关于苯唑西林钠治疗期间肝功能的前瞻性调查显示，41例患者中有5例出现药物相关异常。在每一例中，血清转氨酶水平从正常升高至超过100单位。血清碱性磷酸酶水平轻度升高，胆红素水平保持正常。所有患者均无症状。停用苯唑西林治疗并换用头孢菌素或克林霉素后，肝功能障碍可逆转。观察到的肝功能异常与每日苯唑西林钠剂量大于或等于12克以及海洛因成瘾和葡萄球菌性心内膜炎有关。
