Environmental Genomics and Systems Biology Research Group, Institute for Natural Resource Sciences, Zürich University of Applied Sciences ZHAW, Wädenswil, Switzerland.
Bioinformatics and Systems Biology, Justus-Liebig-Universität, Giessen, Germany.
Arch Microbiol. 2019 Aug;201(6):713-722. doi: 10.1007/s00203-019-01647-7. Epub 2019 Mar 13.
The genus Pantoea contains a broad range of plant-associated bacteria, including some economically important plant pathogens as well as some beneficial members effective as biological control agents of plant pathogens. The most well-characterized representatives of biological control agents from this genus generally produce one or more antimicrobial compounds adding to biocontrol efficacy. Some Pantoea species evaluated as biocontrol agents for fire blight disease of apple and pear produce a histidine-reversible antibiotic. Three commonly studied histidine-reversible antibiotics produced by Pantoea spp. are herbicolin O, MccEh252, and pantocin A. Pantocin A is a novel ribosomally encoded and post-translationally modified peptide natural product. Here, we review the current knowledge on the chemistry, genetics, biosynthesis, and incidence and environmental relevance of pantocin A and related histidine-reversible antibiotics produced by Pantoea.
泛菌属包含广泛的植物相关细菌，包括一些具有经济重要性的植物病原菌，以及一些作为植物病原菌生物防治剂有效的有益成员。该属中最具代表性的生物防治剂通常会产生一种或多种抗菌化合物，从而提高生物防治效果。一些被评估为苹果和梨火疫病生物防治剂的泛菌属物种会产生一种组氨酸可逆抗生素。三种通常研究的由泛菌属产生的组氨酸可逆抗生素是 herbicolin O、MccEh252 和 pantocin A。Pantocin A 是一种新型核糖体编码和翻译后修饰的肽天然产物。在这里，我们综述了关于 pantocin A 和由泛菌属产生的相关组氨酸可逆抗生素的化学、遗传学、生物合成、发生和环境相关性的现有知识。
