Qureshi Mushtaq H, Esper Gregory J, Bashir Ferhad F
Department of Neurology, Texas Tech Health Science Center, Paul Foster School of Medicine, 4800 Alberta Ave, El Paso, TX, USA.
Department of Neurology, Emory Brain Health Center, Atlanta, GA, USA.
Curr Treat Options Neurol. 2019 Mar 14;21(4):15. doi: 10.1007/s11940-019-0560-7.
Headache is not an uncommon complaint in children, and recognition of migraine is increasing in children and adolescents. Treatment options consist of abortive and preventive medications; however, when to start the preventive treatment is not clear in the pediatric population. This article reviews current guidelines and practices to provide a better clinical approach in the management of migraines in children and adolescents.
Currently, the only FDA-approved medical treatment option for preventive therapy in chronic migraine in adolescents is topiramate. However, the Childhood and Adolescent Migraine Prevention Study (CHAMP) did not endorse superiority of topiramate or amitriptyline over placebo. At this time, there is no clear consensus on when to start preventive therapy in children and adolescents with migraines. The decision is multifactorial and should be initiated after a thorough discussion with the patient and caregiver(s) about related risks and benefits of treatment. Education regarding various modalities of treatment and ensuring compliance is essential to treatment success.
头痛在儿童中并非罕见的主诉,儿童和青少年中偏头痛的诊断率正在上升。治疗选择包括急性发作期用药和预防性用药;然而,在儿科人群中,何时开始预防性治疗尚不清楚。本文回顾当前的指南和实践,以提供更好的临床方法来管理儿童和青少年的偏头痛。
目前,美国食品药品监督管理局(FDA)唯一批准用于青少年慢性偏头痛预防性治疗的药物是托吡酯。然而,儿童和青少年偏头痛预防研究(CHAMP)并未认可托吡酯或阿米替林比安慰剂更具优势。目前,对于何时开始对偏头痛儿童和青少年进行预防性治疗尚无明确共识。该决定是多因素的,应在与患者及照顾者充分讨论治疗相关风险和益处后做出。关于各种治疗方式的教育以及确保依从性对于治疗成功至关重要。