回文序列与基因转换过程中的DNA断裂位点相关。
Palindromic sequences are associated with sites of DNA breakage during gene conversion.
作者信息
Krawinkel U, Zoebelein G, Bothwell A L
出版信息
Nucleic Acids Res. 1986 May 12;14(9):3871-82. doi: 10.1093/nar/14.9.3871.
Abstract
Gene conversion is a recombinatorial mechanism which transfers genetic information from a donor into a recipient gene. A case of gene conversion between immunoglobulin VH region genes was analysed and palindromic sequences were found to be located near to the left recombinatorial breakpoint, which also is flanked by a direct repeat sequence. We performed a computer search for palindromes and direct repeats in the published sequences of eucaryotic genes which had been involved in gene conversion. In these sequences, the palindrome with the best or second best quality is located near to a breakpoint of recombination. A correlation of recombination breakpoints with direct repeats was not observed. This suggests that gene conversion is promoted by palindromic sequences.
摘要
基因转换是一种重组机制，它将遗传信息从供体转移到受体基因中。分析了免疫球蛋白VH区域基因之间的一例基因转换情况，发现回文序列位于左重组断点附近，该断点两侧也有一个同向重复序列。我们对已参与基因转换的真核基因的已发表序列进行了回文和同向重复序列的计算机搜索。在这些序列中，质量最佳或次佳的回文序列位于重组断点附近。未观察到重组断点与同向重复序列之间的相关性。这表明回文序列促进了基因转换。
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